Localization of the hydrogen sulfide and oxytocin systems at the depth of the sulci in a porcine model of acute subdural hematoma

作     者：Oscar McCook Angelika Scheuerle Nicole Denoix Thomas Kapapa Peter Radermacher Tamara Merz Oscar McCook;Angelika Scheuerle;Nicole Denoix;Thomas Kapapa;Peter Radermacher;Tamara Merz

作者机构：Institute for Anesthesiological Pathophysiology and Process EngineeringUlm University Medical CenterUlmGermany Department of NeuropathologyUlm University Medical CenterGünzburgGermany Clinic for Psychosomatic Medicine and PsychotherapyUlm University Medical CenterUlmGermany Department of NeurosurgeryUlm University Medical CenterUlmGermany 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2021年第16卷第12期

页      面：2376-2382页

核心收录：

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

基　　金：This work was supported by a grant from the Deutsche Bundeswehr and the Deutsche Forschungsgemeinschaft(DFG,German Research Foundation)-Projektnummer 251293561-SFB 1149(to PR) a grant from the Deutsche Forschungsgemeinschaft(DFG,German Research Foundation)-Projektnummer 251293561-SFB 1149 and Ulm University-Baustein-Programm(to TM) 

主　　题：animal modeling brain edema cystathionine-β-synthase cystathionine-γ-lyase gyrencephalic brain immunohistochemistry intensive care unit large animal model neuromonitoring oxytocin receptor 

摘      要：In the porcine model discussed in this review,the acute subdural hematoma was induced by subdural injection of autologous blood over the left parietal cortex,which led to a transient elevation of the intracerebral pressure,measured by bilateral *** hematoma-induced brain injury was associated with albumin extravasation,oxidative stress,reactive astrogliosis and microglial activation in the ipsilateral *** proteins and injury markers were validated to be used for immunohistochemistry of porcine brain *** cerebral expression patterns of oxytocin,oxytocin receptor,cystathionine-γ-lyase and cystathionine-β-synthase were particularly interesting:these four proteins all co-localized at the base of the sulci,where pressure-induced brain injury elicits maximum *** this context,the pig is a very relevant translational model in contrast to the rodent *** structure of the porcine brain is very similar to the human:the presence of gyri and sulci(gyrencephalic brain),white matter to grey matter proportion and tentorium ***,pressure-induced injury in the porcine brain,unlike in the rodent brain,is reflective of the human pathophysiology.