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Notoginsenoside R1 attenuates breast cancer progression by targeting CCND2 and YBX3

Notoginsenoside R1 attenuates breast cancer progression by targeting CCND2 and YBX3

作     者:Hai-Long Qin Xue-Jun Wang Bi-Xian Yang Bin Du Xue-Lin Yun Qin Hai-Long;Wang Xue-Jun;Yang Bi-Xian;Du Bin;Yun Xue-Lin

作者机构:College of PharmacyGuizhou University of Traditional Chinese MedicineGuiyangGuizhou 550000China College of Food and Pharmacy EngineeringGuiyang UniversityGuiyangGuizhou 550000China 

出 版 物:《Chinese Medical Journal》 (中华医学杂志(英文版))

年 卷 期:2021年第134卷第5期

页      面:546-554页

核心收录:

学科分类:1006[医学-中西医结合] 1002[医学-临床医学] 10[医学] 100602[医学-中西医结合临床] 

基  金:This work was supported by grants from the National Natural Science Foundation of China(No.81260576) the Major Program of Science and Technology Foundation of Guizhou Province(QKHJZ2003) the Major Science and Technology Projects of Guizhou Province(QKHJZ2002-2-5) the Science and Technolo-gy Foundation of Guizhou Province(QKHJY3007). 

主  题:Breast cancer Notoginsenoside Rl CCND2 YBX3 

摘      要:Background:Breast cancer(BC)is a common malignancy with highly female incidence.So far the function of notoginsenoside R1(NGR1),the extract from Panax notoginseng,has not been clearly elucidated in BC.Methods:Optimal culture concentration and time of NGR1 were investigated by cell counting kit-8 assay.Cell proliferation ability was measured by colony formation assays.Transwell assay was used to detect the effect of NGR1 on cell migration and invasion.The apoptosis rate of cells between each group was measured by TUNEL assay.Results:NGR1 treatment has an inhibitory efect on proliferation,migration,invasion,and angiogenesis and a stimulating effect on cell cycle arrest and apoptosis of Michigan Cancer Foundation-7(MCF-7)cells.The 50%growth inhibitory concentration for MCF-7 cells at 24 h was 148.9 mmol/L.The proportions of MCF-7 cells arrested in the G0/G1 phase were 36.94+6.78%,45.06士5.60%,and 59.46+5.60%in the control group,75,and 150 mmol/L groups,respectively.Furthermore,we revealed that NGR1 treatment attenuates BC progression by targeted downregulating CCND2 and YBX3 genes.Additionally,YBX3 activates phosphatidylinositol 3-phosphate kinase(PI3K)/protein kinase B(Akt)signaling pathway by activating kirsten rat sarcoma viral oncogene,which is an activator of the PI3K/Akt signaling pathway.Conclusion:These results suggest that NGR1 can act as an efficacious drug candidate that targets the YBX3/PI3K/Akt axis in patients with BC.

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