Epigenetics of cutaneous T-cell lymphoma:biomarkers and therapeutic potentials

作     者：Pan Lai Yang Wang Pan Lai;Yang Wang

作者机构：Department of Dermatology and VenereologyPeking University First HospitalBeijing Key Laboratory of Molecular Diagnosis on DermatosesNational Clinical Research Center for Skin and Immune DiseasesBeijing 100034China 

出 版 物：《Cancer Biology & Medicine》 (癌症生物学与医学（英文版）)

年 卷 期：2021年第18卷第1期

页      面：34-51页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by grants from the National Natural Science Foundation of China(Grant Nos.81872214 and 81922058)。 

主　　题：Epigenetics cutaneous T-cell lymphoma DNA methylation histone modification micro RNA chromatin-remodeling complex 

摘      要：Cutaneous T-cell lymphomas(CTCLs)are a heterogeneous group of skin-homing non-Hodgkin lymphomas.There are limited options for effective treatment of patients with advanced-stage CTCL,leading to a poor survival rate.Epigenetics plays a pivotal role in regulating gene expression without altering the DNA sequence.Epigenetic alterations are involved in virtually all key cancerassociated pathways and are fundamental to the genesis of cancer.In recent years,the epigenetic hallmarks of CTCL have been gradually elucidated and their potential values in the diagnosis,prognosis,and therapeutic intervention have been clarified.In this review,we summarize the current knowledge of the best-studied epigenetic modifications in CTCL,including DNA methylation,histone modifications,micro RNAs,and chromatin remodelers.These epigenetic regulators are essential in the development of CTCL and provide new insights into the clinical treatments of this refractory disease.