Allylation and alkylation of oxindoleketimines via imine umpolung strategy

作     者：Mei-Hua Shen Chen Li Qing-Song Xu Bin Guo Rui Wang Xiaoqian Liu Hua-Dong Xu Defeng Xu Mei-Hua Shen;Chen Li;Qing-Song Xu;Bin Guo;Rui Wang;Xiaoqian Liu;Hua-Dong Xu;Defeng Xu

作者机构：Jiangsu Key Laboratory of Advanced Catalytic Materials&TechnologySchool of PharmacyChangzhou UniversityChangzhou 213164China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2021年第32卷第7期

页      面：2313-2316页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：the National Natural Science Foundation of China(No.21672027)for financial support supported by High-Level Entrepreneurial Talent Team of Jiangsu Province(No.2017-37) 

主　　题：Allylation Alkylation Azaallylaion Umpolung Oxindleketamine Spiro oxindole 

摘      要：When treated with an alkoxide base like t-BuOK in aprotic solvent,N-di phenyl methyl imino oxindoles,made conveniently through condensation of corresponding isatins with N-di phenyl methyl amine,are deprotonated to form azaallyl *** and alkylation of this type of intermediates proceed smoothly with diverse *** work up finishes 3-amino-3-allyl/alkyl *** overall transformation equals to an umpolung process at the C3 of isatins.