Emerging role of metabolic reprogramming in tumor immune evasion and immunotherapy

作     者：Chunmei Fan Shanshan Zhang Zhaojian Gong Xiayu Li Bo Xiang Hao Deng Ming Zhou Guiyuan Li Yong Li Wei Xiong Zhaoyang Zeng Xiaoling Li Chunmei Fan;Shanshan Zhang;Zhaojian Gong;Xiayu Li;Bo Xiang;Hao Deng;Ming Zhou;Guiyuan Li;Yong Li;Wei Xiong;Zhaoyang Zeng;Xiaoling Li

作者机构：NHC Key Laboratory of CarcinogenesisHumnan Cancer Hospial and the Afiliaed Cancer HospitalXiangva School of MedicineCenral South UniversiyChangsha 410013China Key Laboratory of Carcinogenesis and Cancer Imvasion of the Chinese Minisiry of EducationCancer Research lsite and School of Basic Medical ScienceCentral South UniversitChangsha 410078China Hunan Key Laboralory of Nonresolving Inlammation and CancerDisease Genome Research Cener the Third Xiangya HospitalCenralSouth UniversityChangsha 410013China Department of StomatologyXiangva HospitalCentral Souh UniversityChangsha 410078China Department of Oral and Maillofacial SurgeryThe Second Xiangya HospitalCentral Souh UniversityChangsha 410011China Deparment of MedicineDan L Duncan Comprehensive Cancer CenterBaylor College of MedicineHousionTexasUSA 

出 版 物：《Science China(Life Sciences)》 (中国科学（生命科学英文版）)

年 卷 期：2021年第64卷第4期

页      面：534-547页

核心收录：

学科分类：0710[理学-生物学] 0830[工学-环境科学与工程（可授工学、理学、农学学位）] 1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(81903138,81972776,81803025,81772928,81702907,81772901,81672993,81672683) the Natural Science Foundation of Hunan Province(2019JJ50778,2018SK21210,2018SK21211,2018JJ3704,2018JJ3815)。 

主　　题：tumor microenvironment metabolic reprogramming infiltrating immune cells tumor immune evasion antitumor immunotherapy 

摘      要：Mounting evidence has revealed that the therapeutic efficacy of immunotherapies is restricted to a small portion of cancer patients.A deeper understanding of how metabolic reprogramming in the tumor microenvironment(TME)regulates immunity remains a major challenge to tumor eradication.It has been suggested that metabolic reprogramming in the TME may affect metabolism in immune cells and subsequently suppress immune function.Tumor cells compete with infiltrating immune cells for nutrients and metabolites.Notably,the immunosuppressive TME is characterized by catabolic and anabolic processes that are critical for immune cell function,and elevated inhibitory signals may favor cancer immune evasion.The major energy sources that supply different immune cell subtypes also undergo reprogramming.We herein summarize the metabolic remodeling in tumor cells and different immune cell subtypes and the latest advances underlying the use of metabolic checkpoints in antitumor immunotherapies.In this context,targeting both tumor and immune cell metabolic reprogramming may enhance therapeutic efficacy.