Avian influenza A(H7N9)virus:from low pathogenic to highly pathogenic

作     者：William J.Liu Haixia Xiao Lianpan Dai Di Liu Jianjun Chen Xiaopeng Qi Yuhai Bi Yi Shi George F.Gao Yingxia Liu William J.Liu;Haixia Xiao;Lianpan Dai;Di Liu;Jianjun Chen;Xiaopeng Qi;Yuhai Bi;Yi Shi;George F.Gao;Yingxia Liu

作者机构：Shenzhen Key Laboratory of Pathogen and ImmunityShenzhen Third People’s HospitalShenzhen518114China National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing102206China Laboratory of Protein Engineering and VaccinesTianjin Institute of Industrial BiotechnologyChinese Academy of Sciences(CAS)Tianjin300308China CAS Key Laboratory of Pathogenic Microbiology and ImmunologyInstitute of MicrobiologyChinese Academy of SciencesBeijing100101China CAS Key Laboratory of Special Pathogens and BiosafetyChinese Academy of SciencesWuhan430071China National Virus Resource CenterChinese Academy of SciencesWuhan430071China University of Chinese Academy SciencesBeijing100049China Center for Influenza Research and Early WarningChinese Academy of SciencesBeijing100101China Chinese Center for Disease Control and PreventionBeijing102206China 

出 版 物：《Frontiers of Medicine》 (医学前沿（英文版）)

年 卷 期：2021年第15卷第4期

页      面：507-527页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学] 

基　　金：This study was supported by the Shenzhen Science and Technology Research and Development Project(No.JCYJ201604271519-20801) Innovation Unit for Emerging and Re-emerging Virus Adaptive Evolution Study and the Applications in Disease Control(No.2019-I2M-5-009) National Mega-projects for Infectious Diseases(No.2020ZX10001016-005-001) W.J.L.is supported by the Excellent Young Scientist Program of the NSFC(No.81822040)and Beijing New-star Plan of Science and Technology(No.Z181100006218080) H.X.is supported by Tianjin Synthetic Biotechnology Innovation Capacity Improvement Project(No.TSBICIP-KJGG-004-04) G.F.G.is a leading principal investigator of the National Natural Science Foundation of China Innovative Research Group(No.81621091) 

主　　题：H7N9 HPAIV clinical features epidemiology hemagglutinin immunity pathogenesis vaccine 

摘      要：OriginalTranslation The avian influenza A(H7N9)virus is a zoonotic virus that is closely associated with live poultry *** has caused infections in humans in China since *** waves of the H7N9 influenza epidemic occurred in China between March 2013 and September 2017.H7N9 with low-pathogenicity dominated in the first four waves,whereas highly pathogenic H7N9 influenza emerged in poultry and spread to humans during the fifth wave,causing wide *** and officials from China and other countries responded quickly,controlled the epidemic well thus far,and characterized the virus by using new technologies and surveillance tools that were made possible by their preparedness ***,we review the characteristics of the H7N9 viruses that were identified while controlling the spread of the *** was summarized and discussed from the perspectives of molecular epidemiology,clinical features,virulence and pathogenesis,receptor binding,T-cell responses,monoclonal antibody development,vaccine development,and disease *** data provide tools for minimizing the future threat of H7N9 and other emerging and re-emerging viruses,such as SARS-CoV-2.