Maternal obesity as a risk factor for developing diabetes in offspring:An epigenetic point of view
作者机构：Department of Medicine(H7)Karolinska InstitutetStockholm 141-86Sweden University of LilleEA4489Maternal Malnutrition and Programming of Metabolic DiseasesLille 59000France Clermont-Ferrand CHUDepartment of EndocrinologyDiabetology and Metabolic DiseasesClermont-Ferrand 63003France
出 版 物：《World Journal of Diabetes》 (世界糖尿病杂志（英文版）（电子版）)
年 卷 期：2021年第12卷第4期
页 面：366-382页
核心收录：
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
主 题：Development Epigenome Obesity Type 2 diabetes Adipose tissue Beta cells
摘 要：According to the developmental origin of health and disease concept,the risk of many age-related diseases is not only determined by genetic and adult lifestyle factors but also by factors acting during early *** particular,maternal obesity and neonatal accelerated growth predispose offspring to overweight and type 2 diabetes(T2 D) in *** concept mainly relies on the developmental plasticity of adipose tissue and pancreatic β-cell programming in response to suboptimal milieu during the perinatal *** changes result in unhealthy hypertrophic adipocytes with decreased capacity to store fat,lowgrade inflammation and loss of insulin-producing pancreatic β-*** the past years,many efforts have been made to understand how maternal obesity induces long-lasting adipose tissue and pancreatic β-cell dysfunction in offspring and what are the molecular basis of the transgenerational inheritance of T2 *** particular,rodent studies have shed light on the role of epigenetic mechanisms in linking maternal nutritional manipulations to the risk for T2 D in *** this review,we discuss epigenetic adipocyte and β-cell remodeling during development in the progeny of obese mothers and the persistence of these marks as a basis of obesity and T2 D predisposition.
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