Effects of Yttrium-90 selective internal radiation therapy on non-conventional liver tumors

作     者：Andrew Kuei Sammy Saab Sung-Ki Cho Stephen T Kee Edward Wolfgang Lee 

作者机构：Division of Interventional Radiology Department of Radiology UCLA Medical Center David Geffen School of Medicine at UCLA Los Angeles Department of Medicine Division of Hepatology Pfleger Liver Institute University of California at Los Angeles Los Angeles Division of Interventional Radiology Department of Radiology Samsung Medical Center Sungkyunkwan University School of Medicine 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2015年第21卷第27期

页      面：8271-8283页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 08[工学] 1010[医学-医学技术（可授医学、理学学位）] 100214[医学-肿瘤学] 100106[医学-放射医学] 10[医学] 

主　　题：Liver metastases Breast cancer Melanoma Cholangiocarcinoma Radioembolization Selective internal radiation therapy Transarterial radioembolization Yttrium-90 

摘      要：The liver is a common site of metastasis, with essentially all metastatic malignancies having been known to spread to the liver. Nearly half of all patients with extrahepatic primary cancer have hepatic metastases. The severe prognostic implications of hepatic metastases have made surgical resection an important first line treatment in management. However, limitations such as the presence of extrahepatic spread or poor functional hepatic reserve exclude the majority of patients as surgical candidates, leaving chemotherapy and locoregional therapies as next best options. Selective internal radiation therapy(SIRT) is a form of catheter-based locoregional cancer treatment modality for unresectable tumors, involving trans-arterial injection of microspheres embedded with a radioisotope Yttrium-90. The therapeutic radiation dose is selectively delivered as the microspheres permanently embed themselves within the tumor vascular bed. Use of SIRT has been conventionally aimed at treating primary hepatic tumors(hepatocellular carcinoma) or colorectal and neuroendocrine metastases. Numerous reviews are available for these tumor types. However, little is known or reviewed on non-colorectal or nonneuroendocrine primaries. Therefore, the aim of this paper is to systematically review the current literature to evaluate the effects of Yttrium-90 radioembolization on non-conventional liver tumors including those secondary to breast cancer, cholangiocarcinoma, ocular and percutaneous melanoma, pancreatic cancer, renal cell carcinoma, and lung cancer.