Development of a new biomechanical indicator for primary blast-induced brain injury
Development of a new biomechanical indicator for primary blast-induced brain injury作者机构：Bioengineering Center Wayne State University 818 W. Hancock Detroit M148201 USA
出 版 物：《Chinese Journal of Traumatology》 (中华创伤杂志（英文版）)
年 卷 期：2015年第18卷第1期
页 面：10-12页
核心收录：
学科分类：0710[理学-生物学] 071011[理学-生物物理学] 0403[教育学-体育学] 02[经济学] 0202[经济学-应用经济学] 1002[医学-临床医学] 07[理学]
基 金：supported in part by MRMC Contract
主 题：创伤性脑损伤 生物力学 原发性 力学指标 爆炸 横向加速度 波传播理论 神经元细胞
摘 要：Primary blast-induced traumatic brain injury (bTBI) has been observed at the boundary of brain tissue and cerebrospinal fluid (CSF). Such injury can hardly be explained by using the theory of compressive wave propagation, since both the solid and fluid materials have similar compressibility and thus the intracranial pressure (ICP) has a continuous distribution across the boundary. Since they have completely different shear properties, it is hypothesized the injury at the interface is caused by shear wave. In the present study, a preliminary combined numerical and theoretical analysis was conducted based on the theory of shear wave propagation/reflection. Simulation results show that higher lateral acceleration of brain tissue particles is concentrated in the boundary region. Based on this finding, a new biomechanical vector, termed as strain gradient, was suggested for primary bTBI. The subsequent simple theoretical analysis reveals that this parameter is proportional to the value of lateral acceleration. At the boundary of lateral ventricles, high spatial strain gradient implies that the brain tissue in this area (where neuron cells may be contained) undergo significantly different strains and large velocity discontinuity, which may result in mechanical damage of the neuron cells.
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