Bone morphogenic protein signaling in spinal cord injury

作     者：Nadia Al-Sammarraie Swapan K.Ray Nadia Al-Sammarraie;Swapan K.Ray

作者机构：Department of PathologyMicrobiologyand ImmunologyUniversity of South Carolina School of MedicineColumbiaSC 29209USA 

出 版 物：《Neuroimmunology and Neuroinflammation》 (神经免疫与神经炎症（英文版）)

年 卷 期：2021年第8卷第1期

页      面：53-63页

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

基　　金：The work was supported,in part,by an investigator-initiated research grant(SCIRF-2015-I-01)from the South Carolina Spinal Cord Injury Research Fund(Columbia,SC,USA) an award from the Soy Health Research Program(SHRP,United Soybean Board,Chester昀eld,MO,USA) earlier R01 grants(CA-091460 and NS-057811)from the National Institutes of Health(Bethesda,MD,USA) 

主　　题：Spinal cord injury bone morphogenic protein apoptosis proliferation autophagy differentiation inflammation 

摘      要：Spinal cord injury(SCI)is a debilitating injury that results from traumatic or non-traumatic insults to the spinal cord,causing significant impairment of the patient s activity and quality of *** morphogenic proteins(BMPs)are a group of polyfunctional cytokines belonging to the transforming growth factor beta superfamily that regulates a wide variety of cellular functions in healthy and disease *** studies suggest that dysregulation of BMP signaling is involved in neuronal demyelination and death after traumatic *** focus of this article is to describe our current understanding of the role of BMP signaling in the regulation of cell fate,proliferation,apoptosis,autophagy,and inflammation in traumatic ***,we will describe the expression of BMPs and pattern of BMP signaling before and after traumatic SCI in rodent models and in ***,we will discuss the role of BMP in the regulation of neuronal and glial cell differentiation,survival,functional recovery from traumatic SCI,and the gap in knowledge in this area that requires further investigation to improve SCI prognosis.