p-Terphenyl alcohols from a marine sponge-derived fungus, Aspergillus candidus OUCMDZ-1051

作     者：Dongyang Wang Peng Qu Jiayu Zhou Yi Wang Liping Wang Weiming Zhu Dongyang Wang;Peng Qu;Jiayu Zhou;Yi Wang;Liping Wang;Weiming Zhu

作者机构：Key Laboratory of Marine DrugsMinistry of Education of ChinaSchool of Medicine and PharmacyOcean University of ChinaQingdao 266003China Open Studio for Druggability Research of Marine Natural Products.Laboratory for Marine Drugs and BioproductsPilot National Laboratory for Marine Science and Technology(Qingdao)Qingdao 266003China State Key Laboratory of Functions and Applications of Medicinal PlantsGuizhou Medical UniversityGuiyang 550014China 

出 版 物：《Marine Life Science & Technology》 (海洋生命科学与技术（英文）)

年 卷 期：2020年第2卷第3期

页      面：262-267页

核心收录：

学科分类：0710[理学-生物学] 0831[工学-生物医学工程（可授工学、理学、医学学位）] 0830[工学-环境科学与工程（可授工学、理学、农学学位）] 07[理学] 070703[理学-海洋生物学] 0908[农学-水产] 0707[理学-海洋科学] 0836[工学-生物工程] 0713[理学-生态学] 

基　　金：This work is supported by the National Natural Science Foundation of China(NSFC)(Nos.U1906213 41876172.and U1606403). 

主　　题：Sponge-derived fungus Aspergillus candidus Natural products p-Terphenyl Cytotoxicity Antimicrobial activity 

摘      要：In order to discover structurally new and bioactive conipounds from marine life,we studied the secondary metabolites of the marine-derived fungi associated with a marine sponge(XS-3)from the Xisha islands.As a result,4-O-methylcandidusin A(1),a new p-terphenyl alcohol,along with nine known analogs(2-10),were isolated and identified from the marine spongederived fungus Aspergillus candidus OUCMDZ-1051.The structures of these compounds were determined by analyzing spectroscopic data,especially ID and 2D NMR.The new compound 1 selectively inhibited the growth of the MDA-MB-46&BT474 and A431 human cancer cell lines with the IC_(50) values of 1.84,6.05 and 0.98 pmol/L,respectively.Compound 1 also displayed a selective antimicrobial activity against Escherichia coli with an MIC value of 27.3 pmol/L.The results indicated 4-O-methylcandidusin A(1)as a potential lead in the new drug discovery for triple negative breast cancer,invasive ductal breast cancer and epidermoid cancer.The antimicrobial metabolites also evidenced a clue for chemical defense of sponges by their associated microorganisms.