Spleen-Yang-deficiency patients with polycystic ovary syndrome have higher levels of visfatin

作     者：Huijia Fu Yan Qiu Feng Wei Li Yang Min Xia Huiyu He 

作者机构：Assistant Reproductive Centerthe First Affiliated Hospital of Chongqing Medical University Department of Obstetrics and GynecologyChongqing Traditional Chinese Medicine Hospital Department of Traditional Chinese Medicinethe First Affiliated Hospital of Chongqing Medical University 

出 版 物：《Journal of Traditional Chinese Medicine》 (中医杂志（英文版）)

年 卷 期：2014年第34卷第1期

页      面：42-47页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1005[医学-中医学] 1002[医学-临床医学] 100211[医学-妇产科学] 10[医学] 

基　　金：Supported by Traditional Chinese Medicine Project of Chongqing Municipal Health Bureau China 

主　　题：多囊卵巢综合征 高水 内脂 患者 胰岛素抵抗 中国传统医学 空腹血糖 脾 

摘      要：OBJECTIVE:To study serum visfatin levels in women with polycystic ovary syndrome(PCOS)grouped by Traditional Chinese Medicine(TCM)patterns.To study the correlations of serum visfatin levels with homeostatic model assessment insulin resistance(HOMA-IR),fasting plasma glucose(FPG),fasting insulin(FINS),body mass index(BMI),testosterone(T),total cholesterol(TC),and triglycerides(TG).METHODS:Two hundred and twelve PCOS patients were placed into the following TCM pattern subgroups:Kidney-Yang deficiency(KYD)group,Spleen-Yang deficiency(SYD)group,stagnant Liver-Qi transforming into heat(SLQTH)group,and Kidney-Yin deficiency(KYIND)group.The correlations between serum visfatin levels and HOMA-IR,FPG,FINS,BMI,T,TC,andTG were analyzed.RESULTS:Of all patients with PCOS,there were 82in the KYD group(38.6%),67 in the SYD group(31.6%),37 in the SLQTH group(17.5%),and 26 in the KYIND group(12.3%).Visfatin levels in all PCOS subgroups were higher than those in the control group(P0.05).The SYD group had higher levels of FINS and HOMA-IR compared with the KYD,SLQTH,and KYIND groups(P0.05).In all subgroups,after controlling for BMI,TG,TC,and age,visfatin was positively correlated with FINS(r=0.197,P=0.015)and HOMA-IR(r=0.173,P=0.033),and was not correlated with T.CONCLUSION:KYD and SYD patterns are most common in PCOS patients.Increased visfatin is a common pathophysiologic manifestation in PCOS patients.The SYD group had the highest levels of visfatin,and visfatin was positively correlated with FINS and HOMA-IR.