Progress in TNM staging of pancreatic neuroendocrine tumors

作     者：Taymeyah Al-Toubah Jonathan Strosberg 

作者机构：lee moffitt cancer centerdepartment of gi oncologytampaflusa 

出 版 物：《Hepatobiliary Surgery and Nutrition》 (肝胆外科与营养（英文）)

年 卷 期：2021年第10卷第2期

页      面：238-240页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：staging invasion Figure 

摘      要：In recent years,staging classifications for well-differentiated pancreatic neuroendocrine tumors(NETs)have evolved significantly(1-3).Historical classifications,which attempted to combine clinical,pathological,and radiographic findings,were found to be overly *** was not until 2006 that Rindi et *** a standard four-stage TNM classification,which was subsequently endorsed by the European Neuroendocrine Tumor Society(ENETS)(4).The T stage distinguished between tumors smaller than 2 cm(T1),2-4 cm(T2),4 cm or invading duodenum/bile ducts(T3),and invading adjacent structures(T4).N and M stages were defined simply by the presence or absence of regional lymph nodes and distant metastases(Figure 1A).The American Joint Committee on Cancer(AJCC)seventh edition adopted a different TNM classification in 2010,derived from the staging for pancreatic *** this classification,T1 referred to a tumor2 cm,T3 referred to disease extending beyond the pancreas,and T4 referred to the invasion of the celiac axis or SMA(unresectable).As in the ENETS classification,N and M stage were defined simply by the presence or absence of metastases(Figure 1B).