Changes in sleep parameters following biomimetic oral appliance therapy: A case report

作     者：G Dave Singh Shamshudin Kherani 

作者机构：Institute of Craniofacial Sleep MedicineVivos TherapeuticsInc.Highlands RanchCO 80129United States Dental ClinicKherani Dental at AspenCalgary T3H0N6Canada 

出 版 物：《World Journal of Clinical Cases》 (世界临床病例杂志)

年 卷 期：2021年第9卷第10期

页      面：2312-2319页

核心收录：

学科分类：1002[医学-临床医学] 100213[医学-耳鼻咽喉科学] 10[医学] 

主　　题：Obstructive sleep apnea Biomimetic oral appliance therapy Continuous positive airway pressure Mandibular advancement device Case report 

摘      要：BACKGROUND Mandibular advancement devices(MADs)are used to treat mild to moderate obstructive sleep apnea(OSA),but there is a risk that the underlying condition can worsen in the ***,this case report is based on biomimetic oral appliance therapy as an alternative to MADs,which was found to be beneficial in the treatment of a case with severe *** SUMMARY An overnight sleep study was undertaken in a 50-year-old male with excessive daytime sleepiness that lead to a diagnosis of severe OSA as the apnea-hypopnea index(AHI)was found to be 32.8/*** the patient was unable to comply with continuous positive airway pressure therapy and declined surgical intervention,treatment with a MAD was *** 10 years later,another sleep study was performed with no MAD in the mouth,which revealed an AHI of 67.9/*** view of the deterioration in sleep quality,the patient sought alternative treatment and elected on biomimetic oral appliance therapy,using a mandibular repositioning nighttime appliance(mRNA appliance®,Vivos Therapeutics,Inc.,United States).After 10 mo,another sleep study was performed with no device in the patient’s mouth,which revealed an AHI of 11.8/h,a mean oxygen saturation of 94%and a mean oxygen desaturation index of 5.3%while *** analysis of the pre-and post-treatment study models of the upper jaw showed localized size increases of 15%-17%in the premolar regions and 15%-23%in the molar *** In adults with severe OSA that are unable to accept continuous positive airway pressure or surgical treatment,biomimetic oral appliance therapy may be preferable over MADs since biomimetic oral appliance therapy may be able to prevent worsening of sleep parameters by remodeling the nasomaxillary ***-term follow up studies are required to verify these novel findings.