Research progress of RhoA/ROCK pathway in diabetes-related diseases
作者机构：Gansu University of Chinese MedicineLanzhou730030 Department of Endocrinology of Gansu Provincial HospitalLanzhou730030
出 版 物：《Journal of Hainan Medical University》 (海南医学院学报（英文版）)
年 卷 期：2021年第27卷第5期
页 面：66-70页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：National Natural Science Foundation of China(No.81660148) Innovation and Entrepreneurship Project of Science and Technology Bureau of Chengguan District of Lanzhou City(No.2018HFZ0068) Hospital cultivation Program of Gansu Provincial people's Hospital(No.19SYPYB-4)
主 题：RhoA/ROCK pathway Diabetes-related diseases Inhibitors
摘 要：RhoA is a small GTPase *** downstream effector protein Rho kinase(ROCK)regulates a variety of cell functions,including cell growth,gene expression and cytoskeleton *** have demonstrated that this pathway plays an important pathophysiological role in diabetic nephropathy and other complications,hypertension,stroke,tumor,osteoarthritis,acute lung injury and other *** occurrence and development of diabetes-related disease is closely related to the activation or up-regulation of RhoA/ROCK *** a key target of drug development,ROCK inhibitors have been widely concerned by *** article reviews the relationship between RhoA/ROCK pathway and diabetesrelated disease,and offers a new and effective strategy for the prevention and treatment of this series of diseases.
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