Evaluating Optimal Treatment for Melanoma:A Network Meta-Analysis

作     者：Mengyuan ZHANG Qiong HE Yuifang YU Baolin ZHANG Mengyuan ZHANG;Qiong HE;Yuifang YU;Baolin ZHANG

作者机构：Department of Plastic SurgeryFirst Hospital of Shanxi Medical UniversityTaiyuanShanxi 030001China Department of Endocrinology.First Hospital of Shanxi Medical UniversityTaiyuanShanxi 030001China 

出 版 物：《Chinese Journal of Plastic and Reconstructive Surgery》 (Chin. J. Plast. Reconstr. Surg.)

年 卷 期：2021年第3卷第1期

页      面：27-31页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Melanoma treatment Network Meta-analysis 

摘      要：Background It is necessary to determine the optimal treatment for melanoma as the incidence of melanoma is increasing every *** this study,we conducted a metaanalysis to compare the effectiveness of available treatments for *** The index keywords“melanomaand“treatmentwere used to search the PubMed,Cochrane Library,Web of Science,and Embase databases,and the articles were limited to randomized controlled *** search was filtered for articles published until February 2020,and articles were independently extracted by two *** metaanalysis(Stata®14.0 software network package,StataCorp LLC,TX,USA)was used to compare the effectiveness of the mentioned treatments of *** A total of 616 articles were screened of which 6 were selected for meta-analysis,involving 5 treatment measures and 2047 patients(those who were not followed up on were excluded).The treatment strategies reported for melanoma included tumor necrosis factor(L19-TNFα)and interleukin-2(L19IL2)in combination with dacarbazine(L19IL2+DTIC),DTIC,programmed cell death-1 plus cytotoxic T cell antigen-4(PD-1+CTLA-4),PD-1,and *** Among L19IL2+DTIC,DTIC,PD-1+CTLA-4,PD-1,and CTLA-4,CTLA-4 is found to be the best treatment method for *** study findings provide a reference for the clinical treatment of melanoma and can clarify the direction for setting up controlled clinical trials.