Comparative study on virus shedding patterns in nasopharyngeal and fecal specimens of COVID-19 patients

作     者：Ning Zhang Yuhuan Gong Fanping Meng Yi Shi Jun Wang Panyong Mao Xia Chuai Yuhai Bi Penghui Yang Fusheng Wang Ning Zhang;Yuhuan Gong;Fanping Meng;Yi Shi;Jun Wang;Panyong Mao;Xia Chuai;Yuhai Bi;Penghui Yang;Fusheng Wang

作者机构：CAS Key Laboratory of Pathogenic Microbiology and ImmunologyInstitute of MicrobiologyCenter for Influenza Research and Earlywarning(CASCIRE)CAS-TWAS Center of Excellence for Emerging Infectious Diseases(CEEID)Chinese Academy of SciencesBeijing 100101China Institutes of Physical Science and Information TechnologyAnhui UniversityHefei 230601China The Fifth Medical Center of PLA General HospitalNational Clinical Research Center for Infectious DiseasesBeijing 100039China Department of Pathogenic BiologyHebei Medical UniversityShijiazhuang 050017China Shenzhen Key Laboratory of Pathogen and ImmunitySecond Hospital Affiliated to Southern University of Science and TechnologyShenzhen Third People’s HospitalShenzhen 518112China University of Chinese Academy of SciencesBeijing 101408China 

出 版 物：《Science China(Life Sciences)》 (中国科学（生命科学英文版）)

年 卷 期：2021年第64卷第3期

页      面：486-488页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 10[医学] 

基　　金：the Strategic Priority Research Program of the Chinese Academy of Sciences(CAS)(XDB29010102 and XDA19090118) the National Natural Science Foundation of China(NSFC)(32041010) Hebei Key Research and Development Program(20277704D) Y.B.is supported by the NSFC Outstanding Young Scholars(31822055) Youth Innovation Promotion Association of CAS(2017122). 

主　　题：patients diagnosis urine 

摘      要：Dear Editor,An acute viral pneumonia(COVID-19),caused by the novel coronavirus known as SARS-CoV-2,was first identified during December 2019 in China(Zhu et al.,2020).SARSCoV-2 was found to be highly transmissible in humans(Wang et al.,2020)and is now a pandemic spreading to over 140 countries and causing over 150,000 infections and 6,000 deaths as of March 15,2020.Diagnosis is critical for confirmation and treatment of COVID-19.Currently the primary criterion for diagnosis of COVID-19 is viral RNA detection for respiratory samples.Recently,two studies on virus loads in clinical samples reported that viral loads in nasal and throat swabs and sputum specimens peaked at 3–7 days after illness onset(d.a.o.)and virtually disappeared before 15 d.a.o.(Pan et al.,2020;Zou et al.,2020).Another study showed that the median duration of virus shedding in throat swabs was 20 d.***.o.in survivors and was detectable until death in non-survivors(Zhou et al.,2020).Additionally,live viruses have been isolated in the feces and urine samples of COVID-19 patients.However,the viral dynamics in these types of specimens has not yet been clearly elucidated,as well as comparative studies on virus shedding in the upper respiratory,intestinal,and urinary tracts.