Newly identified genetic variant rs2294693 in UNC5CL gene is associated with decreased risk of esophageal carcinoma in the J&K Population–India
作者机构：Human Genetics Research GroupShri Mata Vaishno Devi UniversityKatraJammu and Kashmir182320India Surgical OncologistSMVD Narayana Super Specialty HospitalKatraJammu and Kashmir182320India
出 版 物：《BIOCELL》 (生物细胞（英文）)
年 卷 期：2021年第45卷第3期
页 面：665-670页
核心收录：
学科分类：0710[理学-生物学] 0831[工学-生物医学工程（可授工学、理学、医学学位）] 1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：Department of Science and Technology Ministry of Science and Technology India डीएसटी (SR/WOS-A/LS1067/2015)
主 题：Esophageal cancer Single nucleotide polymorphism Unc-5 Family C-Terminal(UNC5CL) Candidate gene
摘 要：Esophageal cancer is the second most common type of cancer after lung carcinoma in the state of Jammu and Kashmir(J&K).The understanding of genetics in Esophageal cancer development is poor in the *** wide association studies(GWAS)has proved to be unsurpassed tool in identification of new loci associated with different *** in Chinese population has identified SNP rs2294693 present in UNC5CL(UNC-5 Family C-Terminal like)to be associated with non-cardia gastric *** performed a case control association study and genotyped the SNP rs2294693 using Taqman allele discrimination assay in 566 individuals(166 esophageal cancer patients and 400 controls)belonging to the J&K population.A statistically significant protective association with allelic odds ratio of 0.73(0.56–0.94 at 95%CI)and p value=0.016 was *** is the first study in relation to esophageal cancer in the Jammu and Kashmir population,so far it has been studied in association with gastric carcinoma in the Chinese population *** results indicate that the polymorphism rs2294693 is associated with esophageal cancer susceptibility and the mutant(T)allele might be a protective factor for esophageal cancer among Jammu and Kashmir *** the functional characterization of the variation is also warranted.
维普期刊数据库