Recent advances in the development of colorimetric analysis and testing based on aggregation-induced nanozymes

作     者：Honghong Rao Xin Xue Mingyue Luo Haixia Liu Zhonghua Xue Honghong Rao;Xin Xue;Mingyue Luo;Haixia Liu;Zhonghua Xue

作者机构：College of Chemistry&Chemical EngineeringLanzhou City UniversityLanzhou 730070China Key Laboratory of Bioelectrochemistry&Environmental Analysis of Gansu ProvinceCollege of Chemistry&Chemical EngineeringNorthwest Normal UniversityLanzhou 730070China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2021年第32卷第1期

页      面：25-32页

核心收录：

学科分类：07[理学] 070205[理学-凝聚态物理] 070302[理学-分析化学] 0703[理学-化学] 0702[理学-物理学] 

基　　金：the National Natural Science Foundation of China(Nos.21765013,21665023) Key Talent Project of Gansu Province,“Feitian Scholar”Program of Gansu Province,and the Research Projects of Universities in Gansu Province(No.2017A115)for financially supporting this research。 

主　　题：Colorimetry Nanozymes Aggregation-induced effect Point-of-care testing Naked eye 

摘      要：Colorimetric sensing strategies as a powerful point-of-care testing(POCT) tool have attracted significant interest in various chem/biosensing applications.Taking the excellent bare-eye-detectable signaling feature,nanozymes-based colorimetric sensors enable more potential applications and have been a new forefront in the colorimetric POCT analysis toward different target analytes.However,the low catalytic activity of nanozymes in most cases limits their practical application.Recent efforts demonstrate that the aggregation-induced nanozymes provide a general means to modulate nanozymes activity and enhance colorimetric sensing performances of some nanozymes-based colorimetric sensors.But there are few reports are explored to discuss and review such aggregation-induced nanozymes and their colorimetric sensing applications.To highlight the advances and progress in aggregation-induced nanozymes based colorimetric assays,we herein summary the fundamentals,classify and applications of this newlydeveloping field,focusing on the aggregation-induced activity enhancement of nanozymes(AIAEnanozymes) with a significant signal-on feature and aggregation-induced activity inhibition of nanozymes(AIAI-nanozymes) with a dramatical signal-of characteristics.Finally,we also propose the current challenges and the future prospects on both AIAE-nanozymes and AIAI-nanozymes.