Acute toxicity and oxidative damage induced by silica nanorattle in vivo

作     者：FU ChangHui LIU TianLong TANG FangQiong CHEN Dong LI LinLin LIU HuiYu LI XiaoMin 

作者机构：School of Animal Science and TechnologySouthwest UniversityChongqing 400715China Laboratory of Controllable Preparation and Application of NanomaterialsTechnical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China 

出 版 物：《Chinese Science Bulletin》 (Chinese Science Bulletin)

年 卷 期：2012年第57卷第20期

页      面：2525-2532页

核心收录：

学科分类：100405[医学-卫生毒理学] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(30900349 and 81171454) 

主　　题：急性毒性 二氧化硅 氧化损伤 诱导 体内 超氧化物歧化酶 病理组织学诊断 雌性小鼠 

摘      要：Hollow mesoporous nanomaterial is a kind of promising new drug delivery system due to their unique hollow *** order to evaluate the toxicity of silica nanorattle (SN) particles in vivo,40 female mice were used in this study to investigate the acute toxicity and oxidative *** were intravenously injected with SN suspension in sterile 5% glucose at 40,80 and 240 mg/kg,*** control group was administrated with equal-volume 5% ***,feed intake,hematology analysis,blood biochemical assay and histopathology diagnosis were *** activities of SOD,GSH and CAT were measured as *** results demonstrated that the levels of ALT and AST in the mice treated with 240 mg/kg SN increased significantly as compared with the control group (P0.05),whereas the contents of BUN and CREA changed *** activity of SOD induced by SN in the liver decreased significantly (P0.05).In summary,this study revealed that liver was the target organ of the *** also can be concluded that activity of SOD played an important role in liver injury caused by SN.