Convalescent plasma as a therapeutic agent for SARS-CoV, MERS-CoV and SARS-CoV-2: A scoping review
作者机构：Department of BiotechnologyCollege of Natural and Computational SciencesDebre Berhan UniversityP.O.Box 445Debre BerhanEthiopia Department of BiologyCollege of Natural and Computational SciencesDebre Berhan UniversityP.O.Box 445Debre BerhanEthiopia
出 版 物：《Journal of Acute Disease》 (急性病杂志（英文版）)
年 卷 期：2021年第10卷第2期
页 面：47-56页
学科分类：1007[医学-药学(可授医学、理学学位)] 100705[医学-微生物与生化药学] 1001[医学-基础医学(可授医学、理学学位)] 100103[医学-病原生物学] 10[医学]
主 题：Convalescent plasma Coronaviruses SARS-CoV MERS-CoV SARS-CoV-2 COVID-19
摘 要：Severe acute respiratory syndrome coronavirus(SARS-CoV),Middle East respiratory syndrome coronavirus(MERS-CoV),and SARS-CoV-2 are three kinds of coronaviruses that are exceptionally pathogenic to humans via zoonotic *** outbreaks of SARS-CoV and MERS-CoV,and SARS-CoV-2,to some extent,posed a severe threat to human health,daily activities as well as the economic status of many *** faced with these emerging viruses and no accessible vaccines and drugs,convalescent plasma(CP)is required as passive immunotherapy,since CP has the potential to neutralize and eliminate the virus from blood *** sources of CP are individuals who have recovered from the ***,CP is administered as emergency use and investigational *** studies have shown that CP is effective to treat infected individuals with viral pandemics such as influenza A,Ebola virus,SARS-CoV,and ***,following the deadly outbreak of SARS-CoV-2 in 2019,plenty of non-randomized clinical studies have been done on the effectiveness of CP for the treatment of Coronavirus Disease 2019(COVID-19),and most of these studies have indicated that CP therapy is promising and saved many critically-ill ***,CP is a helpful immune therapeutic agent for the immediate response of such pandemics because of its clinical efficacy,immediate availability,cost-effectiveness,ease of production,delivery,and *** review aims to summarize the effectiveness of CP in the treatment of these three coronaviruses,***-CoV,MERS-CoV,and SARS-CoV-2.
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