An improved scheme for infectious bursal disease virus genotype classification based on both genome-segments A and B
An improved scheme for infectious bursal disease virus genotype classification based on both genome-segments A and B作者机构:Avian Immunosuppressive Diseases DivisionState Key Laboratory of Veterinary BiotechnologyHarbin Veterinary Research InstituteChinese Academy of Agricultural SciencesHarbin 150069P.R.China OIE Reference Laboratory for Infectious Bursal DiseaseHarbin Veterinary Research InstituteChinese Academy of Agricultural SciencesHarbin 150069P.R.China Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Disease and ZoonosisYangzhou 225009P.R.China
出 版 物:《Journal of Integrative Agriculture》 (农业科学学报(英文版))
年 卷 期:2021年第20卷第5期
页 面:1372-1381页
核心收录:
学科分类:090601[农学-基础兽医学] 09[农学] 0906[农学-兽医学]
基 金:the Natural Science Foundation of Heilongjiang Province,China(ZD2020C006 and TD2019C003) the National Key Research and Development Program of China(2016YFE0203200) the Heilongjiang Province Foundation for the National Key Research and Development Program of China(GX18B011) the Major Project of National Natural Science Foundation of China(31430087) the earmarked fund for China Agriculture Research System(CARS-41-G15)
主 题:infectious bursal disease virus genotype VP1 VP2 novel variant strain
摘 要:Infectious bursal disease(IBD)is caused by infectious bursal disease virus(IBDV),which has a genome consisting of two segments of double-stranded linear *** have been traditionally divided into four phenotypes based on their pathogenicity and antigenicity,including classic,variant,very virulent,and attenuated *** the emergences of divergent molecular characteristics of novel strains produced by continuous mutations and recombination,it is increasingly difficult to define new IBDV strains using the traditional descriptive classification *** most common classification scheme for IBDV with segmented genome is based solely on segment A,while the significance of segment B has been largely *** this study,an improved scheme for IBDV genotype classification based on the molecular characteristics of both VP2(a viral capsid protein encoded by segment A)and VP1(an RNA-dependent RNA polymerase protein encoded by segment B)was proposed for the first *** this scheme,IBDV was classified into nine genogroups of A and five genogroups of B,respectively;the genogroup A2 was further divided into four *** commonly used phenotypic classifications of classic,variant,very virulent,and attenuated IBDVs correspond to the A1 B1,A2 B1,A3 B2,and A8 B1 genotypes of the proposed classification *** novel variant IBDVs including the strains identified in this study were classified as belonging to genotype A2 d *** flexibility and versatility of this improved classification scheme will allow the unambiguous identification of existing and emerging IBDV strains,which will greatly facilitate molecular epidemiology studies of IBDV.