Family history of esophageal cancer modifies the association of serum lipids and malignant esophageal lesions:a nested case-control study from the"Endoscopic Screening for Esophageal Cancer in China"trial

作     者：Min-Min Wang Chuan-Hai Guo Feng-Lei Li Rui-Ping Xu Zhen Liu Ya-Qi Pan Fang-Fang Liu Ying Liu Hong Cai Meng-Fei Liu Zhong-Hu He Yang Ke Wang Min-Min;Guo Chuan-Hai;Li Feng-Lei;Xu Rui-Ping;Liu Zhen;Pan Ya-Qi;Liu Fang-Fang;Liu Ying;Cai Hong;Liu Meng-Fei;He Zhong-Hu;Ke Yang

作者机构：Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing)Laboratory of GeneticsPeking University Cancer Hospital and InstituteBeijing 100142China Hua County People's HospitalAnyangHenan 456400China Anyang Cancer HospitalAnyangHenan 455000China 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2021年第134卷第9期

页      面：1079-1086页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by grants from the Charity Project of the National Ministry of Health(No.201202014) the Natural Science Foundation of China(Nos.82073626 and 81773501) the National Key R&D Program of China(No.2016YFC0901404) the National Science&Technology Fundamental Resources Investigation Program of China(No.2019FY101102) the Beijing-Tianjin-Hebei Basic Research Cooperation Project(No.J200016) the Digestive Medical Coordinated Development Center of Beijing Hospitals Authority(No.XXZ0204) the Beijing Natural Science Foundation(No.7182033) the Science Foundation of Peking University Cancer Hospital(No.2020-7)。 

主　　题：Effect modification Esophageal squamous cell carcinoma Family history Genetic susceptibility Lipids and lipoprotein 

摘      要：Background:The association of lipids and cancer has varied greatly among different cancer types,lipid components and study populations.This study is aimed to investigate the association of serum lipids and the risk of malignant lesions in esophageal squamous epithelium.Methods:In theEndoscopic Screening for Esophageal Cancer in China(ESECC)trial,serum samples were collected and tested for total cholesterol(TC),triglycerides,low-density lipoprotein cholesterol(LDL-C),and high-density lipoprotein cholesterol at the time of subject enrollment.Cases were defined as malignant esophageal lesions identified by baseline endoscopic examination or by follow-up to May 31,2018.Controls were randomly selected using incidence density sampling in the same cohort.Conditional logistic models were applied to identify the association of serum lipids and the risk of malignant esophageal lesions.Effect modification was evaluated by testing interaction terms of the factor under assessment and these serum lipid indicators.Results:No consistent association between serum lipid levels and esophageal malignant lesions were found in a pooled analysis of 211 cases and 2101 controls.For individuals with a family history of esophageal cancer(EC),high TC,and LDL-C were associated with a significantly increased risk of having malignant lesions(odds ratio[OR]Highvs.Low TC=2.22,95%confidence interval[CI]:1.14-4.35;ORHighvs.Low LDL-C=1.93,95%CI:1.01-3.65).However,a negative association was observed in participants without an EC family history(ORHighvs.Low TC=0.69,95%CI:0.48-0.98,Pinteraction=0.002;ORHighvs.Low LDL-C=0.50,95%CI:0.34-0.76,Pinteraction0.001).Conclusions:In this study,we found that the association of serum lipids and malignant esophageal lesions might be modified by EC family history.The stratified analysis would be crucial for population-based studies investigating the association of serum lipids and cancer.The mechanism by which a family history of EC modifies this association warrants further investigation.