Mechanism underlying effect of Chaihu Shugan San(柴胡疏肝散)on major depressive disorder:a network pharmacology-based study

作     者：MU Jie ZHANG Shuang TANG Feifei LIU Shuling ZHANG Qianyi DU Qianlei WANG Xueqian WANG Qingguo CHENG Fafeng MU Jie;ZHANG Shuang;TANG Feifei;LIU Shuling;ZHANG Qianyi;DU Qianlei;WANG Xueqian;WANG Qingguo;CHENG Fafeng

作者机构：Clinical basic teaching and Research Office of Traditional Chinese MedicineChengdu University of Traditional Chinese MedicineWenjiang DistrictChengdu 611137China Innovation Team of"Basic Research on Application of Classical Prescription"Teaching and Research Department of Clinical Foundation of Chinese MedicineSchool of Basic Medical SciencesBeijing University of Chinese MedicineBeijing 100029China 

出 版 物：《Journal of Traditional Chinese Medicine》 (中医杂志（英文版）)

年 卷 期：2021年第41卷第2期

页      面：338-348页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：Supported by the General Program of National Natural Science Foundation of China(No.81774122) Young Teachers Project of Beijing University of Chinese Medicine(No.2017-JYB-JS-002),College Level Project of Beijing University of Chinese Medicine(No.2019-JYB-XS-002) Projects of Sichuan Administration of Traditional Chinese Medicine(No.2020JC0035) Xinglin Scholar Project of Chengdu University of Traditional Chinese Medicine(No.BSH2020016) 

主　　题：Depressive disorder,major Pharmacology Chaihu Shugan San 

摘      要：OBJECTIVE:To investigate the mechanism underpinning the effect of Chaihu Shugan San(柴胡疏肝散,CHSGS)on major depressive disorder(MDD).METHODS:We searched the compound components of from seven herbal ingredients of CHSGS from TCMSP,SymMap,ETCM,NPASS databases,and the chemical structure of the compound from PubChem,and collected the compound targets from TCMSP and TargetNet databases,and MDD-related targets from DiseaseGene *** established protein-protein interaction in the STRING *** gene mapping,topology analysis and enrichment analysis,the core targets and pathways of CHSGS for MDD,and the involved biological processes(BP),cell components(CC),and molecular functions(MF)were ***:We collected a total of 1135 CHSGS *** screening by ADME standards and the five rules of Ribinski,we obtained 99 different chemical components with different chemical structures,and related targets of 183 different CHSGS *** the DiseaseGene Network,a total of 740 relevant targets for MDD were *** gene mapping and topological analysis,62 related targets of CHSGS for MDD,24 targets with topological Chinese herbal medicine were *** enrichment analysis,10 relevant pathways and 3 core pathways were obtained with the involvement of 127 BP,27 CC,and 43 ***:There are multiple targets and signaling pathways are involved in the action of CHSGS in the treatment of MDD.