Realization of humoral immunity against SARS-CoV-2 infections

作     者：Yong Lin Zhenyu Zhao Jiaxin Zheng Jia Liu Ailong Huang 

作者机构：Key Laboratory of Molecular Biology of Infectious Diseases(Chinese Ministry of Education)Institute for Viral HepatitisDepartment of Infectious DiseasesThe Second Affliated HospitalChongqing Medical UntversityNo.1 Yixueyuan RoadYuzhong DistrictChongqing 400016China Department of Infectious DiseasesUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina 

出 版 物：《Fundamental Research》 (自然科学基础研究（英文版）)

年 卷 期：2021年第1卷第2期

页      面：186-188页

学科分类：1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 100102[医学-免疫学] 10[医学] 

基　　金：the Major National S&T Program Grant(2017ZX10202203 and 2017ZX10302201 to AH)from the Science and Technology Commission of China the Emergency Project(cstc2020jscx-fyzx0053 to AH)from the Science&Technology Commission of Chongqing the National Natural Science Foundation of China(82002131 to YL) the Natural Science Foundation Project of CQ CSTC(cstc2020jcyj-msxmX0081 to YL) the COVID-19 Emergency Project(CQMUNCP0207 to YL) the Scientific Research Staring Foundation of Chongqing Medical University(X9729 to YL)from Chongqing Medical University 

主　　题：immunity humoral alterations 

摘      要：The coronavirus disease 2019(COVID-19)pandemic,caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),is a major ongoing challenge to global *** being infected by SARS-CoV-2,a specific humoral immune response may be rapidly induced in the host to restrain the viral infection via the production of neutralizing antibodies(NAbs),which are also useful for preventing reinfection[1,2].However,there is a lack of comprehensive understanding of the mechanisms underlying SARS CoV-2 specifc humoral immunity and alterations in immunoglobulin M(1gM)and G(1gG)levels in humans during viral infection.