Low body mass index is an independent predictor of poor long-term prognosis among patients with resectable gastric cancer
作者机构：Department of Pancreatic and Gastric SurgeryNational Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China
出 版 物：《World Journal of Gastrointestinal Oncology》 (世界胃肠肿瘤学杂志（英文版）（电子版）)
年 卷 期：2021年第13卷第3期
页 面：161-173页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：Supported by Capital’s Funds for Health Improvement and Research No.CFH:2018-2-4022
主 题：Gastric cancer Malnutrition Obesity Body mass index Survival benefit
摘 要：BACKGROUND The association between body mass index(BMI)and clinical outcomes remains unclear among patients with resectable gastric *** To investigate the relationship between BMI and long-term survival of gastric cancer *** This retrospective study included 2526 patients who underwent radical gastrectomy for gastric cancer between September 2013 and June *** patients were divided into four groups:Group A(low BMI,18.5 kg/m2),group B(normal BMI,18.5-24.9 kg/m2),group C(overweight,25-29.9 kg/m2),and group D(obese,≥30 kg/m2).Clinicopathological findings and survival outcomes were recorded and *** Preoperative weight loss was more common in the low-BMI group,while diabetes was more common in the obese ***-third gastric cancer accounted for a large proportion of cases in the higher BMI *** perioperative complications tended to increase with *** 5-year overall survival rates were 66.4%for group A,75.0%for group B,77.1%for group C,and 78.6%for group *** 5-year overall survival rate was significantly lower in group A than in group C(P=0.008)or group D(P=0.031).Relative to a normal BMI value,a BMI of18.5 kg/m^(2)was associated with poor survival(hazard ratio:1.558,95%confidence interval:1.125-2.158,P=0.008).CONCLUSION Low BMI,but not high BMI,independently predicted poor survival in patients with resectable gastric cancer.
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