A fully absorbable biomimetic polymeric micelle loaded with cisplatin as drug carrier for cancer therapy

作     者：Weihua Zhuang Boxuan Ma Gongyan Liu Xiaobing Chen Yunbing Wang 

作者机构：National Engineering Research Center for BiomaterialsSichuan UniversityChengdu 610064China Department of Biomass ChemistryNational Engineering Laboratory of Clean Technology of Leather ManufactureSichuan UniversityChengdu 610064China 

出 版 物：《Regenerative Biomaterials》 (再生生物材料（英文版）)

年 卷 期：2018年第5卷第1期

页      面：1-8页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 1002[医学-临床医学] 0805[工学-材料科学与工程（可授工学、理学学位）] 100214[医学-肿瘤学] 10[医学] 

基　　金：This research was supported by National Natural Science Foundation of China(Projects 51403131) Sichuan province Science-Technology Support Plan Project(2016SZ0004) the Programme of Introducing Talents of Discipline to Universities(B16033) China Postdoctoral Science Foundation Funded Project(2015M570783). 

主　　题：drug delivery cisplatin polymeric micelles cancer therapy 

摘      要：cis-dichlorodiammineplatinum(II)(CDDP)-loaded polymeric micelles for cancer therapy have been developed to reduce the serious side effects of cisplatin CDDP.Herein,polymeric micelles incorporated with cisplatin are prepared based on the complexation between CDDP and hydrophilic poly(L-glutamic acid)-b-poly(2-methacryloyloxyethyl phosphorylcholine)(PLG-b-PMPC)diblock copolymers.These CDDP-loaded micelles possess an average size of 91nm with narrow distribution,providing remarkable stability in media containing proteins.The release of CDDP from the micelles is faster at pH 5.0 and pH 6.0 than that at pH 7.4 and in a sustained manner without initial burst release.In addition,there is almost no difference in cellular uptake between these CDDP-loaded micelles and free CDDP.Moreover,in vitro cytotoxicity test shows they possess high efficacy to kill 4T1 cells as compared with free drug.Thus,PLG-b-PMPC copolymer might be a promising carrier for CDDP incorporating in cancer therapy.