Regulation of cell locomotion by nanosecond-laser-induced hydroxyapatite patterning

作     者：Seung-Hoon Um Jaehong Lee In-Seok Song Myoung-Ryul Ok Yu-Chan Kim Hyung-Seop Han Sang-Hoon Rhee Hojeong Jeon 

作者机构：Center for BiomaterialsBiomedical Research InstituteKorea Institute of Science and Technology(KIST)Seoul02792Republic of Korea Department of Dental Biomaterials ScienceDental Research InstituteSchool of DentistrySeoul National UniversitySeoul03080Republic of Korea Department of Oral and Maxillofacial SurgeryKorea University Anam HospitalSeoul02841Republic of Korea Division of Bio-Medical Science and TechnologyKIST SchoolKorea University of Science and TechnologySeoul02792Republic of Korea KU-KIST Graduate School of Converging Science and TechnologyKorea UniversitySeoul02841Republic of Korea 

出 版 物：《Bioactive Materials》 (生物活性材料（英文）)

年 卷 期：2021年第6卷第10期

页      面：3608-3619页

核心收录：

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

基　　金：This work was supported by a National Research Foundation of Korea(NRF)grant funded by the Korean government(MSIT)[grant number 2020R1A2C2010413] the Korea Medical Device Development Fund grant funded by the Korea government(the Ministry of Science and ICT,the Ministry of Trade,Industry and Energy,the Ministry of Health&Welfare,the Ministry of Food and Drug Safety)(NTIS Number:9991007189) the KIST project(grant number 2E31121) the KU-KIST Graduate School of Converging Science and Technology Program 

主　　题：Nanosecond laser Laser engraving Hydroxyapatite patterning Cell migration control Cell tracking 

摘      要：Hydroxyapatite,an essential mineral in human bones composed mainly of calcium and phosphorus,is widely used to coat bone graft and implant surfaces for enhanced biocompatibility and bone *** a strong implant-bone bond,the bone-forming cells must not only adhere to the implant surface but also move to the surface requiring bone ***,strong adhesion tends to inhibit cell migration on the surface of ***,a cell migration highway pattern that can promote cell migration was prepared using a nanosecond laser on hydroxyapatite *** developed surface promoted bone-forming cell movement compared with the unpatterned hydroxyapatite surface,and the cell adhesion and movement speed could be controlled by adjusting the pattern ***-cell microscopy,cell tracking,and serum protein analysis revealed the fundamental principle of this *** findings are applicable to hydroxyapatite-coated biomaterials and can be implemented easily by laser patterning without complicated *** cell migration highway can promote and control cell movement while maintaining the existing advantages of hydroxyapatite ***,it can be applied to the surface treatment of not only implant materials directly bonded to bone but also various implanted biomaterials implanted that require cell movement control.