Inhibitory effects of oxyresveratrol on ERK and Smad1/2 phosphorylation and HSC activation in preventing carbon tetrachloride-induced rat liver fibrosis

作     者：Guliang Yang Jianfeng Zhan Yiwen Yang Li Yuan Peilei Wang Chi-Tang Ho Shiming Li Guliang Yang;Jianfeng Zhan;Yiwen Yang;Li Yuan;Peilei Wang;Chi-Tang Ho;Shiming Li

作者机构：Hubei Key Laboratory of EFGIRHuanggang Normal UniversityHuanggangHubeiChina Department of Food ScienceRutgers UniversityNew BrunswickNJUSA 

出 版 物：《Food Science and Human Wellness》 (食品科学与人类健康（英文）)

年 卷 期：2021年第10卷第1期

页      面：6-12页

核心收录：

学科分类：0832[工学-食品科学与工程（可授工学、农学学位）] 1002[医学-临床医学] 08[工学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 083201[工学-食品科学] 10[医学] 

基　　金：Grant from Hubei Province China(GRANT number 2019ABA100) 

主　　题：Oxyresveratrol Hepatic fibrosis Oxidative stress TGF-β/Smad/ERK signaling pathway 

摘      要：Oxyresveratrol(ORes,trans-2,4,3′,5′-tetrahydroxy stilbene)naturally exists in mulberry,grapes,peanuts and other *** belongs to stilbene polyphenolic family and has an extra hydroxyl group at 2-position comparing with resveratrol(Res).Hence,ORes has stronger antioxidant activity than *** present study,we employed a rat hepatic fibrosis model induced by carbon tetrachloride(CCl_(4))and administrated ORes via gavage feeding to study the protective effects and potential mechanisms of ORes against hepatic *** demonstrated that rat liver oxidative damage induced by CCl_(4)was significantly alleviated after ORes ***,the mRNA transcription levels ofα-smooth muscle actinn(˛-SMA),desmin,and two MMPs(MMP2 and MMP9)were reduced and the expression levels of transforming growth factorβ1(TGF-β1),p-small mother against decapen-taplegic protein(Smad)1/2 and p-extracellular signal-regulated kinases(ERK)1/2 in the liver tissue down-regulated *** a parallel study with Res,ORes showed more efficacious protective effect than Res against rat liver fibrosis,which is attributed to extended conjugation system due to the extra hydroxyl group at 2-position on ORes making it more electron-rich and susceptible to oxidation than ***,dietary consumption of mulberry and other fruits containing ORes may be beneficial in the prevention of liver fibrosis.