Efficacy and safety of once daily tacrolimus compared to twice daily tacrolimus after liver transplantation
作者机构:Department of Liver TransplantationKing Faisal Specialist Hospital and Research CenterRiyadh 12713Saudi Arabia Department on Internal medicineFaculty of MedicineMinia UniversityMina 1234Egypt Department of Liver and Small Bowel Transplantation and Hepatobiliary-Pancreatic SurgeryKing Faisal Specialist Hospital and Research CenterRiyadh 12713Saudi Arabia Organ Transplant CenterKing Faisal Specialist Hosp and Res CtrRiyadh 11211Saudi Arabia
出 版 物:《World Journal of Hepatology》 (世界肝病学杂志(英文版)(电子版))
年 卷 期:2021年第13卷第3期
页 面:375-383页
学科分类:1002[医学-临床医学] 100210[医学-外科学(含:普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学]
主 题:Prolonged release Tacrolimus Liver transplantation Graft rejection Renal impairment FK level
摘 要:BACKGROUND Once daily tacrolimus regimen was found to exhibits similar bioavailability,safety and efficacy properties compared to twice-daily tacrolimus in kidney transplantation *** To compare the efficacy and safety of once-daily prolonged release tacrolimus compared to twice-daily tacrolimus in liver transplantation *** MEDLINE,EMBASE,CENTRAL databases were searched for clinical trials until December *** outcome measured as the rate of treatment failure indicated by biopsy-proven acute rejection,Serum creatinine,graft loss,or *** reviewers independently selected studies,collected data and assessed risk of *** results are reported as risk ratio with 95%confidence interval(CI)for dichotomous *** Seven studies included with 965 *** the included studies were of moderate quality according to the risk of bias assessment using Cochrane Risk of Bias ***-proven acute rejection was reported in four studies,and pooled analysis of those studies indicated similar rejections in both twice daily and once daily tacrolimus groups(risk ratio:1.06,95%CI:0.84-1.34,n=758,I2=0%)and also we found no significant difference between both groups for renal outcome(serum creatinine;mean difference,0.001 mg/dL,95%CI:-0.042 to 0.043,n=846,I2=18.6%).Similarly,there was similar number of adverse events such as hypertension,headache,back pain,blood related disorders,infections and nausea observed in both *** The analysis findings confirm that both once daily and twice daily tacrolimus formulations are comparable in terms of efficacy and safety outcomes.