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Regeneration of dendritic cells in aged mice

Regeneration of dendritic cells in aged mice

作     者:Serani LH van Dommelen Alexandra Rizzitelli Ann Chidgey Richard Boyd Ken Shortman Li Wu 

作者机构:The Walter and Eliza Hall Institute of Medical Research Parkville Vic. Australia Monash Immunology and Stem Cell Laboratories Monash University Clayton Vic. Australia Current address: Department of Biochemistry and Molecular Biology Monash University Clayton Vic. Australia 

出 版 物:《Cellular & Molecular Immunology》 (中国免疫学杂志(英文版))

年 卷 期:2010年第7卷第2期

页      面:108-115页

核心收录:

学科分类:0710[理学-生物学] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 081702[工学-化学工艺] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 07[理学] 08[工学] 0817[工学-化学工程与技术] 071009[理学-细胞生物学] 09[农学] 0901[农学-作物学] 090102[农学-作物遗传育种] 

基  金:National Health and Medical Research Council  NHMRC 

主  题:ageing dendritic cells thymic regeneration 

摘      要:Age-related thymic involution causes a decreased output of thymocytes from the thymus, thereby resulting in impairment of T cell-mediated immunity. While alterations in the T cell and non-haematopoietic stromal compartments have been described, the effects of thymic involution on thymic dendritic cells (DC) are not clearly known. Thymic DC play an essential role in shaping T cell-mediated immune responses by deleting self-reactive thymocytes to establish central tolerance and by inducing regulatory T-cell (Treg) development. It is therefore important to assess the prevalence of and alterations to thymic DC with age, as this may impact on their function. We assessed the numbers and proportions of the three distinct subsets of thymic DC in ageing mice, and showed that these subsets are differentially regulated. This is expected as thymic DC subsets have different origins of development. We further assessed the responses of thymic DC in a regenerative environment, such as that induced by sex-steroid ablation (SSA), and clearly showed that, consistent with global thymus regrowth, all three DC populations increased in numbers and regained their relative proportions to thymocytes after an initial lag period. These findings are important for the clinical translation of thymic regenerative approaches, and indicate that SSA facilitates the maintenance of critical processes such as negative selection and Treg induction through promoting thymic DC regeneration.

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