Overview of genetic causes of recurrent miscarriage and the diagnostic approach

作     者：TAREK A ATIA 

作者机构：Prince Sattam bin Abdulaziz UniversityCollege of Applied Medical SciencesMedical Laboratory Sciences DepartmentAl-kharjSaudi Arabia 

出 版 物：《BIOCELL》 (生物细胞（英文）)

年 卷 期：2019年第43卷第4期

页      面：253-262页

核心收录：

学科分类：0710[理学-生物学] 0831[工学-生物医学工程（可授工学、理学、医学学位）] 1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Recurrent miscarriage Genetic defects Diagnostic approach Chromosomal microarray Next-generation sequencing 

摘      要：Recurring miscarriage(RM)is a frustrating reproductive complication with variable *** genetic defects have been known to play a crucial role in the etiology of *** abnormalities are frequently detected,while other genetic defects cannot be diagnosed through routine research,such as cryptic chromosomal anomalies,single nucleotide polymorphism,single-gene defect,and gene copy number *** laboratories have recently used variable advanced techniques to detect potential genetic abnormalities in couples with RM and/or in products of *** we aim to summarize the known genetic causes of RM,with a focus on the new diagnostic *** of the genetic profile of miscarriages is important for prognosis and potential counseling planning,as well as the prenatal diagnostic strategy in subsequent pregnancies.