Metabolic alterations and vulnerabilities in hepatocellular carcinoma

作     者：Daniel GTenen Li Chai Justin L.Tan 

作者机构：Cancer Science Institute of SingaporeNational University of SingaporeSingapore Harvard Stem Cell InstituteHarvard Medical SchoolBostonMAUSA Department of PathologyBrigham&Women’s HospitalHarvard Medical SchoolBostonMAUSA Experimental Drug Development CentreAgency for ScienceTechnology and Research(A*STAR)Singapore Genome Institute of SingaporeAgency for ScienceTechnology and Research(A*STAR)Singapore 

出 版 物：《Gastroenterology Report》 (胃肠病学报道（英文）)

年 卷 期：2021年第9卷第1期

页      面：1-13,I0001页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by the Genome Institute of Singapore Innovation Fellow Award to J.L.T the Agency for Science,Technology,and Research A*ccelerate Gap Award[ETPL/18-GAP018-R20H]to J.L.T the Singapore Ministry of Health’s National Medical Research Council Singapore Translational Research(STaR)Investigator Award to D.G.T the Singapore Ministry of Education under its Research Centres of Excellence initiative to D.G.T the National Institutes of Health[R35CA197697,P01HL131477]to D.G.T and the National Heart,Lung,and Blood Institute at the National Institutes of Health and Xiu Research Fund[P01HL095489]to L.C 

主　　题：hepatocellular carcinoma(HCC) metabolism metabolic vulnerability targeted therapy 

摘      要：Liver cancer is a serious *** is ranked as the cancer with the second highest number of cancer-related deaths *** carcinoma(HCC),which arises from transformed hepatocytes,is the major subtype of liver *** accounts for 85%of total liver-cancer *** important aspect of HCC that has been actively studied is its *** the liver as the primary site of numerous metabolic processes in the body,it has been shown that the metabolism of HCC cells is highly dysregulated compared to that of normal *** is therefore crucial to understand the metabolic alterations caused by HCC and the underlying mechanisms for these *** deeper understanding will allow diagnostic and therapeutic advancements in the treatment of *** this review,we will summarize the current literature in HCC metabolic alterations,induced vulnerabilities,and potential therapeutic interventions.