Targeting macrophages in cancer immunotherapy
作者机构：Department of ImmunologyInstitute of Basic Medical SciencesChinese Academy of Medical SciencesSchool of Basic MedicinePeking Union Medical CollegeBeijingChina Collaborative Innovation Center for BiotherapyInstitute of Basic Medical SciencesChinese Academy of Medical SciencesSchool of Basic MedicinePeking Union Medical CollegeBeijingChina
出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)
年 卷 期：2021年第6卷第4期
页 面：1212-1232页
核心收录：
学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100214[医学-肿瘤学] 10[医学]
基 金：This work was supported by the National Natural Science Foundation of China(NSFC)(No.81672914),(No.81472654)(Y.Luo),(No.81601374)(Z.Duan) the Fundamental Research Funds for the Central Universities(3332020033,Z.Duan).
主 题：immunotherapy cancer treatment
摘 要：Immunotherapy is regarded as the most promising treatment for cancers.Various cancer immunotherapies,including adoptive cellular immunotherapy,tumor vaccines,antibodies,immune checkpoint inhibitors,and small-molecule inhibitors,have achieved certain successes.In this review,we summarize the role of macrophages in current immunotherapies and the advantages of targeting macrophages.To better understand and make better use of this type of cell,their development and differentiation characteristics,categories,typical markers,and functions were collated at the beginning of the review.Therapeutic strategies based on or combined with macrophages have the potential to improve the treatment efficacy of cancer therapies.
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