Gastric cancer:Animal studies on the risk of hypoacidity and hypergastrinemia

作     者：Reidar Fossmark Gunnar Qvigstad Helge L Waldum 

作者机构：Department of Gastroenterology and HepatologySt.Olav'sHospitalTrondheimNorway Department of Cancer Researchand Molecular MedicineFaculty of MedicineNorwegianUniversity of Science and TechnologyTrondheim 7006Norway Department of Gastroenterology and HepatologySt.Olav’sHospitalTrondheimNorway 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2008年第14卷第11期

页      面：1646-1651页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：The Norwegian Gastroenterologist Association 

主　　题：Gash'in Gastric cancer Proton pump inhibitors Acid secretion Animal model 

摘      要：Gastric hypoacidity and hypergastrinaemia are seen in several conditions associated with an increased risk of gastric *** and hypergastrinaemia are closely related and their long-term effects are difficult to study separately in *** using animal models can provide valuable information about risk factors and mechanisms in gastric cancer development as the models allow a high degree of intervention when introducing or eliminating factors possibly affecting *** this report,we briefly review findings from relevant animal studies on this *** models of gastric hypoacidity and hypergastrinaemia provide evidence hypergastrinaemia is a common causative factor in many otherwise diverse *** all species where sufficient hypoacidity and hypergastrinaemia have been induced,a proportion of the animals develop malignant lesions in the gastric oxyntic mucosa.