Expression of PD-1/PD-L1 in lung adenocarcinoma and its clinical significance

作     者：Jian Li Yimin Chen Jian Li;Yimin Chen

作者机构：Department of RespirationEmeishan People's HospitalEmeishan 614200China 

出 版 物：《Oncology and Translational Medicine》 (肿瘤学与转化医学（英文版）)

年 卷 期：2021年第7卷第1期

页      面：15-19页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Supported by a grant from the Sichuan Health Appropriate Technology Promotion Project(No.2017yz-00158)。 

主　　题：lung adenocarcinoma PD-1 PD-L1 gene mutation 

摘      要：Objective This study aimed to investigate PD-1/PD-L1 expression in lung adenocarcinoma and its relationship with EGFR/KRAS mutation.Methods The expression levels of PD-1 and PD-L1 in lung adenocarcinoma were detected.Clinicopathological parameters were collected and followed up.The effects of PD-1 and PD-L1 expression on clinicopathological parameters and prognosis of patients with lung adenocarcinoma were statistically analyzed.Results PD-L1 and PD-1 were mainly located in the membrane and cytoplasm of tumor cells.The positive expression rates of PD-1 and PD-L1 were 53%and 40%,respectively.Positive PD-1 expression had a significant effect on the incidence of KRAS mutation(P0.05).EGFR gene mutation,high PD-1 expression,high PD-L1 expression,N stage,and AJCC stage were independent risk factors of DFS(P0.05).Conclusion High PD-1/PD-L1 expression is closely related to the occurrence of lung adenocarcinoma and can be used as an independent factor to assess the prognosis of patients with lung adenocarcinoma.There were negative correlations between PD-L1 expression and EGFR mutation and between PD-1 expression and KRAS mutation.