MAFLD vs.NAFLD:shared features and potential changes in epidemiology,pathophysiology,diagnosis,and pharmacotherapy

作     者：Ying-Xin Xian Jian-Ping Weng Fen Xu Xian Ying-Xin;Weng Jian-Ping;Xu Fen

作者机构：Department of Endocrinology and MetabolismThe Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong 510630China Guangdong Provincial Key Laboratory of DiabetologyGuangzhouGuangdong 510630China Department of Endocrinology of the First Affiliated HospitalDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui 230001China 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2021年第134卷第1期

页      面：8-19页

核心收录：

学科分类：1002[医学-临床医学] 10[医学] 

基　　金：supported by grants from the National Natural Science Foundation of China(Nos.81670782 and 81970741) the Local Innovative and Research Teams Projects of Guangdong Pearl River Talents Program(No.2017BT01S131) the Guangdong High-Level Talents Special Support Program(No.2016TQ03R590) Pearl River S&T Nova Program of Guangzhou(No.201610010175)。 

主　　题：Nonalcoholic fatty liver disease Metabolic(dysfunction)associated fatty liver disease Epidemiology Pathophysiology Diagnosis Pharmacotherapy 

摘      要：Nonalcoholic fatty liver disease(NAFLD)is the most common chronic liver disease worldwide,placing an increasing burden on human health.NAFLD is a complex multifactorial disease involving genetic,metabolic,and environmental factors.It is closely associated with metabolic syndrome,obesity,and type 2 diabetes,of which insulin resistance is the main pathophysiological mechanism.Over the past few decades,investigation of the pathogenesis,diagnosis,and treatments has revealed different aspects of NAFLD,challenging the accuracy of definition and therapeutic strategy for the clinical practice.Recently,experts reach a consensus that NAFLD does not reflect the current knowledge,and metabolic(dysfunction)associated fatty liver disease(MAFLD)is suggested as a more appropriate term.The new definition puts increased emphasis on the important role of metabolic dysfunction in it.Herein,the shared features and potential changes in epidemiology,pathophysiology,diagnosis,and pharmacotherapy of the newly defined MAFLD,as compared with the formerly defined NAFLD,are reviewed for updating our understanding.