3D confined self-assembling of QD within super-engineering block copolymers as biocompatible superparticles enabling stimulus responsive solid state fluorescence
作者机构：School of Materials and EnergyUniversity of Electronic Science and Technology of ChinaChengdu 611731China The Avram and Stella Goldstein-Goren Department of Biotechnology EngineeringBert-Gurion University of the NegevBeer-Sheva 8410501Israel State Key Laboratory of BiotherapySichuan UniversityChengdu 610051China
出 版 物：《Nano Research》 (纳米研究（英文版）)
年 卷 期：2021年第14卷第1期
页 面：285-294页
核心收录：
学科分类：0808[工学-电气工程] 07[理学] 0809[工学-电子科学与技术（可授工学、理学学位）] 070303[理学-有机化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学] 0702[理学-物理学]
基 金：the National Natural Science Foundation of China(No.51403029) the Fundamental Research Funds for the Central Universities(No.ZYGX2019J026) Sichuan Science and Technology Program(No.2020YFG0100) International Science and Technology Cooperation Project from Chengdu municipal government(No.2019-GH02-00037-HZ).K.J.thanks Prof.Yanbo Li from the IoF of UESTC for his timely assistance in fluorescence lifetime measurement.
主 题：three-dimensional(3D)confinement self-assembly quantum dots amphiphilic polyarylene ether nitrile stimulus responsive fluorescence
摘 要：Eliminating colloidal toxicity and enabling its intrinsic fluorescence in aggressive environmental conditions are the key challenges for commercializing hydrophobic cadmium based quantum dots(QD).Polyarylene ether nitriles(PEN)are an example of super-engineering thermoplastics that possess a unique combination of thermal stability,intrinsic fluorescence,biocompatibility and distinct emulsion self-assembly feature.Herein,the co-self-assembly of amphiphilic PEN with hydrophobic CdSe@ZnS QD,confined in the three-dimensional(3D)oil-in-water emulsion droplets,has been explored tofabricate fluorescent microparticles(FMP).It was found that these FMP demonstrated good biocompatibility(cell viability above 90%),while exhibiting a fluorescence emission in aqueous solution that was retained(intensity retention ratio above 80%)within the whole pH range of 1-14,as well as,after being subjected to autoclaving at 120℃for 1 h.Interestingly,it was discovered that introduction of calcium ions in the emulsion self-assembly contributed to in-situ generation of phase changing nanoplates inside the FMP,which led to the photo-thermal modulated solid state fluorescence from drop-casted FMP film.Thanks to their versatile fluorescence,these FMP colloids were exploited as fluorescent probes for macrophages imaging,while micro-patterns with reversible changing of emission color were induced via thermal treatment and direct laser lithography.
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