Vancomycin-induced thrombocytopenia in endocarditis:A case report and review of literature

作     者：Si-Ri Guleng Ri-Han Wu Xiao-Bin Guo 

作者机构：Department of PharmacyInner Mongolia Autonomous Region People's HospitalHohhot 010010Inner Mongolia AutonomousChina 

出 版 物：《World Journal of Clinical Cases》 (世界临床病例杂志)

年 卷 期：2021年第9卷第7期

页      面：1696-1704页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：The Inner Mongolia Autonomous Region People's Hospital Training Talent Research Start-up Fund No.BS201703 

主　　题：Case report Vancomycin Thrombocytopenia Endocarditis Platelet transfusion Literature review 

摘      要：BACKGROUND Thrombocytopenia is a serious complication in the medical practice of numerous *** is frequently used for the prophylaxis and treatment of suspected or identified methicillin-resistant positive *** cases with vancomycin-induced thrombocytopenia(VIT)have been ***,these have rarely been extensively *** present report describes a case of VIT in endocarditis,and reviews all VIT cases reported in the *** SUMMARY A 26-year-old male diagnosed with infective endocarditis was *** patient was treated with multiple drugs,including vancomycin,which was initially intravenously given at 1000 mg every 12 h and subsequently at 500 mg every 8 h on day *** day 11,the platelet count decreased to 51×10^(9)/L,vancomycin was switched to 500 mg every 12 h,and platelet transfusion was *** day 17,the platelet count dropped to 27×10^(9)/L,and platelet transfusion was administered *** day 23,vancomycin was adjusted to 500 mg every 8 h as the trough concentration dropped to the minimum effective *** day 33,the platelet count declined to approximately 40×10^(9)/*** platelet transfusion,the platelet count rebounded to 90×10^(9)/L on day 35 but dropped again to 42×10^(9)/L on day *** on the time-to-platelet count curve and Naranjo’s Adverse Drug Reaction Probability Scale score,VIT was *** vancomycin discontinuation and platelet transfusion,the platelet count gradually *** The diagnosis of VIT can be achieved through the time-to-platelet count curve and Naranjo’s Adverse Drug Reaction Probability Scale *** platelet count cannot be normalized simply by platelet transfusion alone,and vancomycin discontinuation is essential.