Mouse models of epithelial ovarian cancer for preclinical studies

作     者：Sergey Karakashev Ru-Gang Zhang Sergey Karakashev;Ru-Gang Zhang

作者机构：ImmunologyMicroenvironment&Metastasis ProgramThe Wistar InstitutePhiladelphiaPA 19104USA 

出 版 物：《Zoological Research》 (动物学研究（英文）)

年 卷 期：2021年第42卷第2期

页      面：153-160页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by the US National Institutes of Health (R01CA160331, R01CA163377, R01CA202919,R01CA239128, P01AG031862, P50CA228991 to R.G.Z. and K99CA241395 to S.K.) US Department of Defense (OC180109 and OC190181 to R.G.Z.) The Honorable Tina Brozman Foundation for Ovarian Cancer Research (to R.G.Z.) Ovarian Cancer Research Alliance Collaborative Research Development Grant (to R.G.Z.) Core facilities support was provided by a Cancer Centre Support Grant(CA010815) to the Wistar Institute 

主　　题：Epithelial ovarian cancer Patientderived xenografts Orthotopic mouse model Subcutaneous mouse model Intraperitoneal mouse model Syngeneic mouse model Genetic engineered mouse model 

摘      要：Epithelial ovarian cancer(EOC) is the leading cause of gynecological cancer-related mortality in the developed world. EOC is a heterogeneous disease represented by several histological and molecular subtypes. Therefore, exploration of relevant preclinical animal models that consider the heterogenic nature of EOC is of great importance for the development of novel therapeutic strategies that can be translated clinically to combat this devastating disease. In this review, we discuss recent progress in the development of preclinical mouse models for EOC study as well as their advantages and limitations.