A nomogram-based immune-serum scoring system predicts overall survival in patients with lung adenocarcinoma

作     者：Qiujuan Huang Tongyuan Qu Lisha Qi Changxu Liu Yuhong Guo Qianru Guo Guangning Li Yalei Wang Wenshuai Zhang Wei Zhao Danyang Ren Leina Sun Shengguang Wang Bin Meng Baocun Sun Bin Zhang Wenjuan Ma Wenfeng Cao Qiujuan Huang;Tongyuan Qu;Lisha Qi;Changxu Liu;Yuhong Guo;Qianru Guo;Guangning Li;Yalei Wang;Wenshuai Zhang;Wei Zhao;Danyang Ren;Leina Sun;Shengguang Wang;Bin Meng;Baocun Sun;Bin Zhang;Wenjuan Ma;Wenfeng Cao

作者机构：Department of PathologyTianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinTianjin’s Clinical Research Center for CancerTianjin 300060China Department of PathologyTianjin Academy of Traditional Chinese Medicine Affiliated HospitalTianjin 300120China Department of Lung CancerTianjin Lung Cancer Center Department of Breast Cancer Department of Breast ImagingKey Laboratory of Breast Cancer Prevention and TherapyTianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinTianjin’s Clinical Research Center for CancerTianjin 300060China 

出 版 物：《Cancer Biology & Medicine》 (癌症生物学与医学（英文版）)

年 卷 期：2021年第18卷第2期

页      面：517-529页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by the Tianjin Municipal Health Bureau Science and Technology Foundation(Grant No.16KG125) the Project of the National Natural Science Foundation of China(Grant No.81801781) the Project of Tumor Translational Medicine Seed Fund of the Tianjin Medical University Cancer Institute and Hospital(Grant No.1905) 

主　　题：Lung adenocarcinoma immune microenvironment nomogram immunoscore prognosis 

摘      要：Objective:The immunoscore,which is used to quantify immune infiltrates,has greater relative prognostic value than tumor,node,and metastasis(TNM)stage and might serve as a new system for classification of colorectal ***,a comparable immunoscore for predicting lung adenocarcinoma(LUAD)prognosis is currently ***:We analyzed the expression of 18 immune features by immunohistochemistry in 171 *** relationship of immune marker expression and clinicopathologic factors to the overall survival(OS)was analyzed with the Kaplan-Meier method.A nomogram was developed by using the optimal features selected by least absolute shrinkage and selection operator(LASSO)regression in the training cohort(n=111)and evaluated in the validation cohort(n=60).Results:The indicators integrated in the nomogram were TNM stage,neuron-specific enolase,carcino-embryonic antigen,CD8 center of tumor(CT),CD8 invasive margin(IM),Fox P3 CT,and CD45 *** calibration curve showed prominent agreement between the observed 2-and 5-year OS and that predicted by the *** simplify the nomogram,we developed a new immune-serum scoring system(I-SSS)based on the points awarded for each factor in the *** I-SSS was able to stratify same-stage patients into different risk *** combination of I-SSS and TNM stage had better prognostic value than the TNM stage ***:Our new I-SSS can accurately and individually predict LUAD prognosis and may be used to supplement prognostication based on the TNM stage.