Heterologous viral suppressor of RNA silencing breaks protein-based viral immunity in mixed viral infection

作     者：Xu Lu Feng Li Xu Lu;Feng Li

作者机构：Key laboratory of Horticultural Plant Biology(MOE)College of Horticulture and Forestry SciencesHuazhong Agricultural UniversityWuhan 430070China Interdisciplinary Sciences Research InstituteHuazhong Agricultural UniversityWuhan 430070China 

出 版 物：《Science China(Life Sciences)》 (中国科学（生命科学英文版）)

年 卷 期：2021年第64卷第10期

页      面：1788-1791页

核心收录：

学科分类：1001[医学-基础医学(可授医学、理学学位)] 100102[医学-免疫学] 10[医学] 

基　　金：supported by the National Key Research and Development Program of China(2018YFD1000800) the National Natural Science Foundation of China(91940301) Department of Science and Technology of Hubei Province(2019AHB070) 

主　　题：immunity infection 

摘      要：Dear Editor:RNA silencing confers immunity against most viruses and is initiated by host Dicer processing of viral doublestranded RNA into virus-derived small interfering RNA(siRNA)(Guo et al.,2019).Viruses that cause plant disease usually evolve viral suppressor of RNA silencing(VSR)to inhibit antiviral silencing(Li and Ding,2006).Some plant nucleotide-binding leucine-rich repeat proteins(NLRs)emerge as immune receptors to recognize specific virus and trigger rapid hypersensitive response(HR)at infection site to protect plants from devastating viruses(Cui et al.,2015;Deng et al.,2018).Recent studies showed that NLR immune receptors are subjected to negative regulation by plant miRNAs(Deng et al.,2018).It is well known that in some cases,mixed virus infections lead to synergism in susceptible plants due to cooperative inhibition of antiviral silencing by multiple VSRs(Pruss et al.,1997).In case of mixed virus infection in a plant with NLR targeting a single virus,heterologous VSR might play dual roles for the NLR-targeted *** one hand,the VSR may promote virulence by cooperative inhibition of antiviral silencing.