Cardiac cell type-specific responses to injury and contributions to heart regeneration
作者机构：Division of Medical Genetics and GenomicsChildren’s HospitalZhejiang University School of Medicine and National Clinical Research Center for Child HealthHangzhouChina
出 版 物：《Cell Regeneration》 (细胞再生（英文）)
年 卷 期：2021年第10卷第1期
页 面：35-43页
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
基 金：The research in the Han’s lab is supported by the National Natural Science Foundation of China(31871462) the National Key R&D Program of China(2018YFA0800501,2018YFC1004801)
主 题：Heart regeneration Cardiomyocytes Endocardial cells Epicardial cells Fibroblasts Immune cells
摘 要：Heart disease is the leading cause of mortality *** to the limited proliferation rate of mature cardiomyocytes,adult mammalian hearts are unable to regenerate damaged cardiac muscle following ***,injured area is replaced by fibrotic scar tissue,which may lead to irreversible cardiac remodeling and organ *** contrast,adult zebrafish and neonatal mammalian possess the capacity for heart regeneration and have been widely used as experimental *** studies have shown that multiple types of cells within the heart can respond to injury with the activation of distinct signaling *** the specific contributions of each cell type is essential for our understanding of the regeneration network organization throughout the *** this review,we provide an overview of the distinct functions and coordinated cell behaviors of several major cell types including cardiomyocytes,endocardial cells,epicardial cells,fibroblasts,and immune *** topic focuses on their specific responses and cellular plasticity after injury,and potential therapeutic applications.
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