A microporous surface containing Si3N4/Ta microparticles of PEKK exhibits both antibacterial and osteogenic activity for inducing cellular response and improving osseointegration

作     者：Xinglong Hu Shiqi Mei Fan Wang Songchao Tang Dong Xie Chao Ding Wenli Du Jun Zhao Lili Yang Zhaoying Wu Jie Wei 

作者机构：Key Laboratory for Ultrafine Materials of Ministry of EducationEast China University of Science and TechnologyShanghai200237China Spine CenterDepartment of OrthopaedicsShanghai Changzheng HospitalSecond Military Medical UniversityShanghai200003China Shanghai Key Laboratory of StomatologyShanghai Research Institute of StomatologyDepartment of OrthodonticsNinth People’s Hospital Affiliated to Shanghai Jiao Tong UniversitySchool of MedicineShanghai200011China School of Biomedical EngineeringSun Yat-sen UniversityGuangzhouGuangdong510006China 

出 版 物：《Bioactive Materials》 (生物活性材料（英文）)

年 卷 期：2021年第6卷第10期

页      面：3136-3149页

核心收录：

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

基　　金：The grants were supported by the National Natural Science Foundation of China(81771990,81801845 and 81200815) Key Medical Program of Science and Technology Development of Shanghai(19441906100 and 17441902000) Shenzhen Fundamental Research Program(JCYJ20190807160811355) 

主　　题：Silicon nitride Tantalum Polyetherketoneketone Antibacterial activity Osseointegration 

摘      要：As an implantable biomaterial,polyetherketoneketone(PEKK)exhibits good mechanical strength but it is biologically inert while tantalum(Ta)possesses outstanding osteogenic bioactivity but has a high density and elastic ***,silicon nitride(SN)has osteogenic and antibacterial *** this study,a microporous surface containing both SN and Ta microparticles on PEKK(STP)exhibiting excellent osteogenic and antibacterial activity was created by *** with sulfonated PEKK(SPK)without microparticles,the surface properties(roughness,surface energy,hydrophilicity and protein adsorption)of STP significantly increased due to the SN and Ta particles presence on the microporous *** addition,STP also exhibited outstanding antibacterial activity,which inhibited bacterial growth in vitro and prevented bacterial infection in vivo because of the presence of SN ***,the microporous surface of STP containing both SN and Ta particles remarkably induced response(e.g.,proliferation and differentiation)of rat bone mesenchymal stem(rBMS)cells in ***,STP significantly improved new bone regeneration and osseointegration in *** the induction of cellular response in vitro and improvement of osseointegration in vivo,the microporous surface containing Ta was better than the surface with SN *** conclusion,STP with optimized surface properties activated cellular responses in vitro,enhanced osseointegration and prevented infection in ***,STP possessed the dual biofunctions of excellent osteogenic and antibacterial activity,showing great potential as a bone substitute.