Cylindrical polymer brushes-anisotropic unimolecular micelle drug delivery system for enhancing the effectiveness of chemotherapy
作者机构：Key Laboratory of Luminescence Analysis and Molecular Sensing(Southwest University)Ministry of EducationSchool of Materials and EnergySouthwest UniversityChongqing400715PR China State Key Laboratory of Molecular Engineering of PolymersFudan UniversityShanghai200438China Chongqing Engineering Research Center for Micro-Nano Biomedical Materials and DevicesSouthwest UniversityChongqing400715PR China
出 版 物：《Bioactive Materials》 (生物活性材料（英文）)
年 卷 期：2021年第6卷第9期
页 面：2894-2904页
核心收录：
学科分类：0710[理学-生物学] 0831[工学-生物医学工程（可授工学、理学、医学学位）] 1002[医学-临床医学] 0805[工学-材料科学与工程（可授工学、理学学位）] 100214[医学-肿瘤学] 0836[工学-生物工程] 10[医学]
基 金：This work was financially supported by National Natural Science Foundation of China(51703187,31671037) the Basic and Frontier Research Project of Chongqing(cstc2018jcyjAX0104)
主 题：Cylindrical polymer brushes Unimolecular micelles Prodrug Reduction-responsive Cancer therapy
摘 要：Polymer systems can be designed into different structures and morphologies according to their physical and chemical performance requirements,and are considered as one of the most promising controlled delivery systems that can effectively improve the cancer therapeutic ***,the majority of the polymer delivery systems are designed to be simple spherical *** explore morphology/size-oriented delivery performance optimization,here,we synthesized three novel cylindrical polymer brushes(CPBs)by atom transfer radical polymerization(ATRP),which were cellulose-g-(CPT-b-OEGMA)(CCO)with different lengths(~86,~40,and~21 nm).The CPBs are composed of bio-degradable cellulose as the carrier,poly(ethylene glycol)methyl ether methacrylate(OEGMA)as hydrophily block,and glutathione(GSH)-responsive hydrophobic camptothecin(CPT)monomer as loaded anticancer *** controlling the chain length of the initiator,three kinds of polymeric prodrugs with different lengths(CCO-1,CCO-2,and CCO-3)could be self-organized into unimolecular micelles in *** carried out comparative studies of three polymers,whose results verified that the shorter CPBs exhibited higher drug release efficiency,more cellular uptake,and enhanced tumor permeability,accompanied by shortened blood circulation time and lower tumor *** evidenced by in vivo experiments,the shorter CPBs exhibited higher anti-tumor efficiency,revealing that the size advantage has a higher priority than the anisotropic structure *** provided vital information as to design an anisotropic polymer-based drug delivery system for cancer therapy.
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