Facile pathway to generate agrochemical nanosuspensions integrating super-high load, eco-friendly excipients, intensified preparation process, and enhanced potency

作     者：Zhengxi Zhu Chuanhua Shao Yanlin Guo Jianguo Feng Chong Chen and Haibin Yang Zhengxi Zhu;Chuanhua Shao;Yanlin Guo;Jianguo Feng;Chong Chen;Haibin Yang

作者机构：School of Chemistry and Chemical EngineeringYangzhou UniversityYangzhou 225002China School of Horticulture and Plant ProtectionYangzhou UniversityYangzhou 225002China Testing CenterYangzhou UniversityYangzhou 225002China 

出 版 物：《Nano Research》 (纳米研究（英文版）)

年 卷 期：2021年第14卷第7期

页      面：2179-2187页

核心收录：

学科分类：0808[工学-电气工程] 081704[工学-应用化学] 0809[工学-电子科学与技术（可授工学、理学学位）] 07[理学] 08[工学] 0817[工学-化学工程与技术] 0805[工学-材料科学与工程（可授工学、理学学位）] 070303[理学-有机化学] 0703[理学-化学] 0702[理学-物理学] 

基　　金：The work was financially supported by the National Natural Science Foundation of China(No.21544005) the Basic Research Program(Natural Science Foundation for Young Scholars)of Jiangsu Province(No.BK20170489) the Materials and Chemical Engineering Research Center of Xinjiang Production and Construction Corps(No.2018BTRC003) the Joint Project of Yangzhou City and Higher Education Institutions(No.YZ2019127) the Innovation Incubation Project of Yangzhou University(No.2019CXJ025) the Priority Academic Program Development of Jiangsu Higher Education Institutions 

主　　题：turbulent confined jet mixing flash nanoprecipitation agrochemical nanosuspensions super-high loads high biological efficacy eco-friendly formulations 

摘      要：An aqueous nanosuspension of agrochemicals unlike pharmaceutics has to achieve massive production in an effective way,capable to ensure sufficient profits in *** work implements the flash nanoprecipitation(FNP)technique to effectively generate agrochemical nanosuspension,anticipatedly overcoming such an ***,a broad spectrum fungicide,in either acetone or ethanol is used herein as a mode *** ensure a green and practical utilization,three kinds of commercially available and eco-friendly surfactants,i.e.,poly(ethylene glycol)-block-poly(lactic-co-glycolic acid)(PEG-b-PLGA),Tween 80 and alkyl polyglucosides(APGs),are employed for stabilizing the *** results show that the polymeric stabilizer,PEG-b-PLGA,has the best stabilization efficiency,and can maintain the particles below 100 nm for at least three *** azoxystrobin load of the nanoparticles reaches as high as 77 wt.%,beneficial to enhancing the biological ***,the FNP brings the particles a much smaller size,narrower size distribution,better size stability,and higher biological efficacy than the ones made via a traditional method of the drop and stir(DS).The nanosuspensions present superior fungicidal performances over a prevailing counterpart from *** study proves an enhanced biological potency and reduced dosage of agrochemical nanosuspension made via the FNP,indicating a remarkable advantage of the FNP over the conventional *** integration of a super-high load,eco-friendly excipients,intensified preparation process,enhanced potency,and reduced dosage creates a promising pathway to generate a green aqueous nanosuspension of agrochemicals.