A SPE-HPLC-MS/MS method for the simultaneous determination of pr ior itised pharmaceuticals and EDCs with high environmental risk potential in freshwater

作     者：Yuan Li MarkATaggart Craig McKenzie Zulin Zhang Yonglong Lu Sabolc Pap Stuart WGibb Yuan Li;Mark A.Taggart;Craig McKenzie;Zulin Zhang;Yonglong Lu;Sabolc Pap;Stuart W.Gibb

作者机构：Environmental Research InstituteNorth Highland CollegeUniversity of the Highlands and IslandsCastle StreetThursoCaithnessScotlandKW147JDUK Forensic Drug Research GroupCentre for Anatomy and Human IdentificationSchool of Science and EngineeringUK Environm ental and Biochem ical Sciences GroupJa m es Hutton InstituteCraigiebucklerA berdeen AB158QHUK Research Centre for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China University of Novi SadFaculty of Technical SciencesDepartment of Environmental Engineering and Occupational Safety and H ealthUniversity of Novi Sad21000 NoviSadSerbia 不详 

出 版 物：《Journal of Environmental Sciences》 (环境科学学报（英文版）)

年 卷 期：2021年第33卷第2期

页      面：18-27页

核心收录：

学科分类：0830[工学-环境科学与工程（可授工学、理学、农学学位）] 08[工学] 0804[工学-仪器科学与技术] 

基　　金：Hydro Nation Scholars Programme Rural and Environment Science and Analytical Services Division, RESAS Scottish Government 

主　　题：Pharmaceuticals prioritisation Risk assessment trace level determination Water quality 

摘      要：This work describes the development,optimisation and validation of an analytical method for the rapid determination of 17 priority pharmaceutical compounds and endocrine disrupting chemicals(EDCs).Rather than studying compounds from the same therapeutic class,the analyses aimed to determine target compounds with the highest risk potential(with particular regard to Scotland),providing a tool for further monitoring in different water matrices.Prioritisation was based on a systematic environmental risk assessment approach,using consumption data;wastewater treatment removal efficiency;environmental occurrence;toxicological effects;and pre-existing regulatory indicators.This process highlighted 17 compounds across various therapeutic classes,which were then quantified,at environmentally relevant concentrations,by a single analytical methodology.Analytical determination was achieved using a single-step solid phase extraction(SPE)procedure followed by high-performance liquid chromatography with tandem mass spectrometry(HPLC-MS/MS).The fully optimised method performed well for the majority of target compounds,with recoveries71%for 15 of 17 analytes.The limits of quantification for most target analytes(14 of 17)ranged from 0.07 ng/L to 1.88 ng/L in river waters.The utility of this method was then demonstrated using real water samples associated with a rural hospital/setting.Eight compounds were targeted and detected,with the highest levels found for the analgesic,paracetamol(at up to 105,910 ng/L in the hospital discharge).This method offers a robust tool to monitor high priority pharmaceutical and EDC levels in various aqueous sample matrices.