Monitoring of edema progression in permanent and transient MCAO model using SS-OCT
作者机构：School of Control Engineering Northeastern University at QinhuangdaoQinhuangdao 066004P.R.China School of Computer Science and Engineering Northeastern UniversityShenyang 110169P.R.China
出 版 物：《Journal of Innovative Optical Health Sciences》 (创新光学健康科学杂志（英文）)
年 卷 期：2021年第4卷第1期
页 面：63-71页
核心收录：
学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 0808[工学-电气工程] 0809[工学-电子科学与技术（可授工学、理学学位）] 08[工学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0836[工学-生物工程] 0702[理学-物理学]
基 金：This work was supported in part by National Natural Science Foundation of China(61771119 and 61901100) Hebei Provincial Natural Science Foundation of China(H2018501087 and H2019501010) Fundamental Research Funds for the Central Universities(N182304008)
主 题：Swept-source optical coherence tomography ischemic stroke cerebral edema optical attenuation coefficient middle cerebral artery occlusion
摘 要：Cerebral edema is a severe complication of acute ischemic stroke with high mortality but limited *** parameters such as brain water content and intracranial pressure may represent the global assessment of edema,optical properties can appear heterogeneously throughout the cerebral tissue relative to the site of *** this study,we have monitored the edema formation and progression in both permanent and transient middle cerebral artery oc-clusion models in *** was reflected by the decrease of optical attenuation coefficient(OAC)value in OCT *** utilizing swept-source optical coherence tomography(SS-OCT),we found that in photochemically induced permanent focal stroke model,both the edema size and edema index,steadily developed until the end of monitor(7 h).Comparatively,when transient ischemia was introduced with endothelin-1(ET-1),the edema was detected as early as 15 min,and began to recover after 30 min until monitor was finished(3 h).Despite the majority of the edema being recovered to some extent,the condition of a small region within the edema kept deteriorating,presumably due to the reperfusion damage which might result in serious clinical *** study has compared the edema characteristics from two different acute ischemic stroke *** work not only confirms the capability of OCT to temporal and spatial monitor of edema but is also able to locate focal conditions at some areas that might highly determine the prognosis and treatment decisions.
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