Understanding the scale-up of fermentation processes from the viewpoint of the flow field in bioreactors and the physiological response of strains

作     者：Jianye Xia Guan Wang Meng Fan Min Chen Zeyu Wang Yingping Zhuang Jianye Xia;Guan Wang;Meng Fan;Min Chen;Zeyu Wang;Yingping Zhuang

作者机构：State Key Laboratory of Bioreactor EngineeringEast China University of Science and TechnologyShanghai 200237China 

出 版 物：《Chinese Journal of Chemical Engineering》 (中国化学工程学报（英文版）)

年 卷 期：2021年第34卷第2期

页      面：178-184页

核心收录：

学科分类：081703[工学-生物化工] 08[工学] 0817[工学-化学工程与技术] 0836[工学-生物工程] 082203[工学-发酵工程] 0822[工学-轻工技术与工程] 

基　　金：The authors would like to acknowledge the Projects 21776082 and 21978085 supported by National Natural Science Foundation of China Project 22221818014 supported by the Fundamental Research Funds for the Central Universities 

主　　题：Fermentation Scale-up Bioreactors Gas-liquid flow Kinetics 

摘      要：The production capability of a fermentation process is predominately determined by individual strains,which ultimately affected ultimately by interactions between the scale-dependent flow field developed within bioreactors and the physiological response of these *** these complicated interactions is key for better understanding the scale-up of the fermentation *** review these two aspects and address progress in strategies for scaling up fermentation processes.A perspective on how to incorporate the multiomics big data into the scale-up strategy is presented to improve the design and operation of industrial fermentation processes.