Role of genetic and environmental factors in DNA methylation of lipid metabolism

作     者：Zhen He Rong Zhang Feng Jiang Wenjing Hou Cheng Hu 

作者机构：Shanghai Diabetes InstituteShanghai Key Laboratory of Diabetes MellitusShanghai Clinical Center for DiabetesShanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghaiChina Institute for Metabolic DiseasesShanghai Jiao Tong University Affiliated Sixth People’s Hospital South CampusShanghaiChina Fengxian Central HospitalAffiliated to Southern Medical University6600 Nanfeng RoadShanghai201499China 

出 版 物：《Genes & Diseases》 (基因与疾病（英文）)

年 卷 期：2018年第5卷第1期

页      面：9-15页

核心收录：

学科分类：0710[理学-生物学] 0831[工学-生物医学工程（可授工学、理学、医学学位）] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100214[医学-肿瘤学] 0703[理学-化学] 10[医学] 

基　　金：This work was supported by the grant from Outstanding Academic Leaders of Shanghai Heath System[2017BR008]. 

主　　题：DNA methylation Environmental exposure Gene expression Genetic variations Lipid metabolism 

摘      要：A number of recent studies revealed that DNA methylation plays a central role in the regulation of lipid metabolism.DNA methylation modifications are important regulators of transcriptional networks that do not affect the DNA sequence and can translate genetic variants and environmental factors into phenotypic traits.Therefore,elucidating the factors that underlie inter-individual DNA methylation variations gives us an opportunity to predict diseases and interfere with the establishment of aberrant DNA methylation early.In this review,we summarize the findings of DNA methylation-related studies focused on unravelling the potential role of genetic and environmental factors in DNA methylation and the regulatory effect of DNA methylation on gene expression in lipid metabolism.